IMATINIB LOADED PEGYLATED POLY PROPYLENE IMINE DENDRIMER FOR DELIVERY TO LEUKEMIC CELLS; FABRICATION OF FORMULATION AND EVALUATION

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KARTHIKEYAN RAMADOSS; KUMAR PALANIRAJANVIJAYRAJ; SAI KOUSHIK ORUGANTI

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Journal: International Journal of Nano Dimension Year:2016 | Volume:7 | Issue:4 Page(s): 336-348

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Title

IMATINIB LOADED PEGYLATED POLY PROPYLENE IMINE DENDRIMER FOR DELIVERY TO LEUKEMIC CELLS; FABRICATION OF FORMULATION AND EVALUATION

Author(s)

KARTHIKEYAN RAMADOSS | KUMAR PALANIRAJANVIJAYRAJ | SAI KOUSHIK ORUGANTI | Issue Writer Certificate

Keywords

ANTILEUKEMIC ACTIVITY

DENDRITIC SCAFFOLD

IMATINIB

PEGYLATED DENDRIMERS

PROLONGED RELEASE

Abstract

PEGylated polypropyleneimine (PPI) DENDRITIC SCAFFOLD was used for the delivery of an anti-leukemic drug, IMATINIB. The current study evolves and emerges the use PEGylated PPI DENDRITIC SCAFFOLD for the delivery of this drug. In this IMATINIB was synthesized and loaded with PEGylated PPI DENDRITIC SCAFFOLD. Parameters such as FT-IR, NMR, SEM, drug release, DSC and hemolytictoxicity are required. Other parameters such as drug entrapment of both PEGylated and non-PEGylated systems were comparatively determined. Drugloading capacity was found to be increased with the PEGylation and reduces the haemolytic toxicity as well as drug release rate. By this, prolonged delivery of IMATINIB was found to be suitable with this system. By delivering the drug for a prolonged period of time at a controlled rate, we expect that this approach will improve the management of drug therapy in leukemic patients.

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APA: Copy

KARTHIKEYAN, RAMADOSS, KUMAR, PALANIRAJANVIJAYRAJ, & SAI KOUSHIK, ORUGANTI. (2016). IMATINIB LOADED PEGYLATED POLY PROPYLENE IMINE DENDRIMER FOR DELIVERY TO LEUKEMIC CELLS; FABRICATION OF FORMULATION AND EVALUATION. INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND), 7(4), 336-348. SID. https://sid.ir/paper/322342/en

Vancouver: Copy

KARTHIKEYAN RAMADOSS, KUMAR PALANIRAJANVIJAYRAJ, SAI KOUSHIK ORUGANTI. IMATINIB LOADED PEGYLATED POLY PROPYLENE IMINE DENDRIMER FOR DELIVERY TO LEUKEMIC CELLS; FABRICATION OF FORMULATION AND EVALUATION. INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND)[Internet]. 2016;7(4):336-348. Available from: https://sid.ir/paper/322342/en

IEEE: Copy

RAMADOSS KARTHIKEYAN, PALANIRAJANVIJAYRAJ KUMAR, and ORUGANTI SAI KOUSHIK, “IMATINIB LOADED PEGYLATED POLY PROPYLENE IMINE DENDRIMER FOR DELIVERY TO LEUKEMIC CELLS; FABRICATION OF FORMULATION AND EVALUATION,” INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND), vol. 7, no. 4, pp. 336–348, 2016, [Online]. Available: https://sid.ir/paper/322342/en

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