FE3O4@SIO2-NH2 AS AN EFFICIENT NANOMAGNETIC CARRIER FOR CONTROLLED LOADING AND RELEASE OF ACYCLOVIR

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAYEBEE REZA; FATTAHI ABDIZADEH MOJTABA; MOHAMMADPOUR AMINI MOSTAFA; MOLLANIA NASRIN; JALILLI ZAHRA; AKBARZADEH HAMED

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Nano Dimension Year:2017 | Volume:8 | Issue:4 Page(s): 365-372

Download Full-Text

View:

228

Download:

514

Cites:

Information Journal Paper

Title

FE3O4@SIO2-NH2 AS AN EFFICIENT NANOMAGNETIC CARRIER FOR CONTROLLED LOADING AND RELEASE OF ACYCLOVIR

Author(s)

Keywords

AMINE FUNCTIONALIZED

ACYCLOVIR

DRUG DELIVERY

MAGNETITE

SILICA

XRD

Abstract

Considering many applications of functionalized metal oxide nanoparticles in magnetic resonance imaging, DRUG DELIVERY, neutron irradiation, electronics, catalysis and optics; herein, a new strategy is developed to functionalize MAGNETITE nanoparticles to improve their performances in the delivery of ACYCLOVIR. In this study, MAGNETITE Fe3O4 nanoparticles are synthesized by hydrothermal method. Then, the surface hydroxyl groups were extended by treating with TEOS (tetraethyl orthosilicate); Finally, TMPA (trimethoxysilylpropylamine) was anchored to the surface hydroxyl groups to produce amino-functionalized Fe3O4@SiO2-NH2 magnetic nanoparticles. The synthesized sample was characterized by UV-Vis, FESEM, FT-IR, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of ACYCLOVIR as an active antiviral drug model involving amine and hydroxyl functional groups. For this purpose, the amount of loading/release of the drug was investigated in different pHs, including mouth and stomach pH values. The screened experimental parameters in this study revealed that the prepared MAGNETITE nanoparticles decorated with amine functional groups are successful in the controlled delivery of ACYCLOVIR.

Cites