COMPARISON OF PARENTERAL PROMETHAZINE VERSUS MIDAZOLAM EFFECT AS A PREOPERATIVE MEDICATION ON POSTOPERATIVE NAUSEA AND VOMITING AFTER APPENDECTOMY

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SHIRDASHTZADEH NASRIN; ESHRAGHI NAZANIN; ESHRAGHI AZADEH

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Journal: Caspian Journal of Internal Medicine Year:2011 | Volume:2 | Issue:3 Page(s): 270-273

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Title

COMPARISON OF PARENTERAL PROMETHAZINE VERSUS MIDAZOLAM EFFECT AS A PREOPERATIVE MEDICATION ON POSTOPERATIVE NAUSEA AND VOMITING AFTER APPENDECTOMY

Author(s)

SHIRDASHTZADEH NASRIN | ESHRAGHI NAZANIN | ESHRAGHI AZADEH | Issue Writer Certificate

Keywords

MIDAZOLAM

POSTOPERATIVE NAUSEA HAVE VOMITING

PROMETHAZINE

Abstract

Background: Postoperative nausea and vomiting is a high unpleasant symptom in surgical procedures. This study compares the effectiveness of MIDAZOLAM with PROMETHAZINE as multipurpose drug in postoperative nausea and vomiting as a preoperative and anesthetic medication after appendectomy.Methods: This randomized, double-blind clinical trial study was performed in patients who underwent appendectomy.These patients randomly received either placebo or MIDAZOLAM or PROMETHAZINE 5 minutes before appendectomy. All episodes of vomiting and nausea within 24 hours after surgery were recorded. The study population (N=75) comprised 3 comparable subgroups (N=25 in each group). A standard general anesthetic technique and postoperative analgesia were used. Data were collected and analyzed.Results: Vomiting and nausea occurred in 19.20%, 0% and 81.80% of the patients in the MIDAZOLAM, PROMETHAZINE and placebo groups, respectively. The frequency of postoperative nausea and vomiting was as follows: the first 6 hours after surgery 0%, 0% and 50%, during the second 6 hours after surgery 19%, 0% and 19%, during the third 6 hours after surgery 0%, 0% and 7%, during the forth 6 hours after surgery 0%, 0% and 4% in the MIDAZOLAM, PROMETHAZINE and placebo groups, respectively. There were no significant differences between PROMETHAZINE with MIDAZOLAM in reduction of postoperative nausea and vomiting.Conclusion: Our study suggest that MIDAZOLAM can be used as multipurpose drugs in postoperative nausea and vomiting as a preoperative medication after appendectomy and treatment using MIDAZOLAM for anti-emetic prophylaxis provide a similar effect compared to PROMETHAZINE in the present study.

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APA: Copy

SHIRDASHTZADEH, NASRIN, ESHRAGHI, NAZANIN, & ESHRAGHI, AZADEH. (2011). COMPARISON OF PARENTERAL PROMETHAZINE VERSUS MIDAZOLAM EFFECT AS A PREOPERATIVE MEDICATION ON POSTOPERATIVE NAUSEA AND VOMITING AFTER APPENDECTOMY. CASPIAN JOURNAL OF INTERNAL MEDICINE, 2(3), 270-273. SID. https://sid.ir/paper/323205/en

Vancouver: Copy

SHIRDASHTZADEH NASRIN, ESHRAGHI NAZANIN, ESHRAGHI AZADEH. COMPARISON OF PARENTERAL PROMETHAZINE VERSUS MIDAZOLAM EFFECT AS A PREOPERATIVE MEDICATION ON POSTOPERATIVE NAUSEA AND VOMITING AFTER APPENDECTOMY. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2011;2(3):270-273. Available from: https://sid.ir/paper/323205/en

IEEE: Copy

NASRIN SHIRDASHTZADEH, NAZANIN ESHRAGHI, and AZADEH ESHRAGHI, “COMPARISON OF PARENTERAL PROMETHAZINE VERSUS MIDAZOLAM EFFECT AS A PREOPERATIVE MEDICATION ON POSTOPERATIVE NAUSEA AND VOMITING AFTER APPENDECTOMY,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 2, no. 3, pp. 270–273, 2011, [Online]. Available: https://sid.ir/paper/323205/en

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