CIRCULATING BASIC FIBROBLAST GROWTH FACTOR IN SERUM OF GASTRIC ULCERS PATIENT AS A BIOMARKER OF WOUND SEVERITY

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SHIRVAI ABDOLHOSSEIN; AHMADI FARIBA; PARSIAN HADI; SHIRKHANI KELAGARI ZIBA; QUJEQ DURDI; TAHERI HASSAN; KASHIFARD MEHRDAD

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Journal: Caspian Journal of Internal Medicine Year:2011 | Volume:2 | Issue:3 Page(s): 261-265

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Title

CIRCULATING BASIC FIBROBLAST GROWTH FACTOR IN SERUM OF GASTRIC ULCERS PATIENT AS A BIOMARKER OF WOUND SEVERITY

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Keywords

BASIC FIBROBLAST GROWTH FACTOR

GASTRIC ULCER

WOUND SEVERITY

Abstract

Background: BASIC FIBROBLAST GROWTH FACTOR (bFGF) is a glycoprotein with stimulating ability of angiogenesis. In addition, bFGF plays an important role in wound healing process in some tissues for example gastrointestinal tract, but its ability for discrimination of various stages of WOUND SEVERITY in these diseases was not reported. Therefore, we aimed to determine the bFGF levels in GASTRIC ULCER patients compared with healthy control as a biomarker for staging the severity of wound Methods: The study group consisted of 33 patients with GASTRIC ULCER and 27 healthy controls. The diagnosis of patients was based on standard clinical, endoscopic, and histological criteria. Serum levels of bFGF were analyzed by an ELISA kit. Results: According to the histological findings, 19 (57.6%) patients were in moderate stage of ulcer and 14 (42.4%) patients were in the severe stage of GASTRIC ULCER. The mean bFGF serum levels in patients group (7.8±1.3pg/ml) were lower than the healthy group (8.2±1.4pg/ml) in crude data, but in statistical analysis the differences were not significant (p=0.082). The mean bFGF serum levels in patients with severe stage of GASTRIC ULCER were greater than patients in moderate GASTRIC ULCER (8.4±1.3 vs. 7.4±1.2 pg) and the differences were statistically significant (p<0.05).Conclusion: Differences in serum bFGF levels in patients with severe stage of GASTRIC ULCER vs. moderate GASTRIC ULCER was significant. Therefore, serum bFGF level measurements can be used as a useful clinical tool for discrimination of patients with severe stage of GASTRIC ULCER vs. moderate GASTRIC ULCER, when endoscopic and histological examination are not possible to perform.

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APA: Copy

SHIRVAI, ABDOLHOSSEIN, AHMADI, FARIBA, PARSIAN, HADI, SHIRKHANI KELAGARI, ZIBA, QUJEQ, DURDI, TAHERI, HASSAN, & KASHIFARD, MEHRDAD. (2011). CIRCULATING BASIC FIBROBLAST GROWTH FACTOR IN SERUM OF GASTRIC ULCERS PATIENT AS A BIOMARKER OF WOUND SEVERITY. CASPIAN JOURNAL OF INTERNAL MEDICINE, 2(3), 261-265. SID. https://sid.ir/paper/323206/en

Vancouver: Copy

SHIRVAI ABDOLHOSSEIN, AHMADI FARIBA, PARSIAN HADI, SHIRKHANI KELAGARI ZIBA, QUJEQ DURDI, TAHERI HASSAN, KASHIFARD MEHRDAD. CIRCULATING BASIC FIBROBLAST GROWTH FACTOR IN SERUM OF GASTRIC ULCERS PATIENT AS A BIOMARKER OF WOUND SEVERITY. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2011;2(3):261-265. Available from: https://sid.ir/paper/323206/en

IEEE: Copy

ABDOLHOSSEIN SHIRVAI, FARIBA AHMADI, HADI PARSIAN, ZIBA SHIRKHANI KELAGARI, DURDI QUJEQ, HASSAN TAHERI, and MEHRDAD KASHIFARD, “CIRCULATING BASIC FIBROBLAST GROWTH FACTOR IN SERUM OF GASTRIC ULCERS PATIENT AS A BIOMARKER OF WOUND SEVERITY,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 2, no. 3, pp. 261–265, 2011, [Online]. Available: https://sid.ir/paper/323206/en

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