مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

STEROID HORMONE RECEPTORS, MIB-1, P53, AND C-ERB-B2 EXPRESSION ON BREAST CANCER: COMPARISON OF IMMUNOHISTOCHEMISTRY ON CELL BLOCK AND FINE NEEDLE ASPIRATION AND TISSUE SAMPLE, IN NORTHWEST IRAN

Pages

  523-529

Abstract

 Background: FINE-NEEDLE ASPIRATION of BREAST CANCER often provides moderate cellular material that is representative of the tumors. These samples can be used not only for cytological diagnosis but also to obtain information on the prognosis and likely response to therapy by using immunohistochemical staining studies.Methods: We assessed the degree of correlation between prognostic biologic markers by means IMMUNOHISTOCHEMISTRY (IHC) on cytoblock obtained from FINE-NEEDLE ASPIRATION (FNA) and immunohistochemical determination on their corresponding tissue sample of five markers; steroid hormone receptors, MIB-1 (Ki-67), P53, and c-erb-B-2 (Her2/neu) in 45 mastectomy of BREAST CANCER.Results: Interobserver reproducibility ranged from 93 to 100%, depending on the marker. A good correlation was observed between immunostaining assessment on cytoblock and on their corresponding tumor tissues as follows: Ki-67 (87%), ER (80%), PR (93%), P53 (96%), and c-erb-B-2 (76%).Conclusion: We conclude that cytoblock prepared from FINE-NEEDLE ASPIRATION specimens of BREAST CANCER is a useful and noninvasive procedure when planning neoadjuvant treatment.

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    APA: Copy

    MARDANPOUR, KEYKHOSRO, & RAHBAR, MAHTAB. (2012). STEROID HORMONE RECEPTORS, MIB-1, P53, AND C-ERB-B2 EXPRESSION ON BREAST CANCER: COMPARISON OF IMMUNOHISTOCHEMISTRY ON CELL BLOCK AND FINE NEEDLE ASPIRATION AND TISSUE SAMPLE, IN NORTHWEST IRAN. CASPIAN JOURNAL OF INTERNAL MEDICINE, 3(4 (12)), 523-529. SID. https://sid.ir/paper/323267/en

    Vancouver: Copy

    MARDANPOUR KEYKHOSRO, RAHBAR MAHTAB. STEROID HORMONE RECEPTORS, MIB-1, P53, AND C-ERB-B2 EXPRESSION ON BREAST CANCER: COMPARISON OF IMMUNOHISTOCHEMISTRY ON CELL BLOCK AND FINE NEEDLE ASPIRATION AND TISSUE SAMPLE, IN NORTHWEST IRAN. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2012;3(4 (12)):523-529. Available from: https://sid.ir/paper/323267/en

    IEEE: Copy

    KEYKHOSRO MARDANPOUR, and MAHTAB RAHBAR, “STEROID HORMONE RECEPTORS, MIB-1, P53, AND C-ERB-B2 EXPRESSION ON BREAST CANCER: COMPARISON OF IMMUNOHISTOCHEMISTRY ON CELL BLOCK AND FINE NEEDLE ASPIRATION AND TISSUE SAMPLE, IN NORTHWEST IRAN,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 3, no. 4 (12), pp. 523–529, 2012, [Online]. Available: https://sid.ir/paper/323267/en

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