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Information Journal Paper

Title

THE EFFECT OF RESVERATROL ON THE EXPRESSION OF MDR1 GENE IN LEUKEMIC LYMPHOBLAST’S OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (SHORT COMMUNICATION)

Pages

  113-115

Abstract

 Background: Chemotherapy plays a very important role in the treatment of leukemia but the resistance properties of the lymphoblasts limit the effect of chemotherapy. One of the main mechanisms of resistance to chemotherapy is the increased expression of MDR1 gene. The aim of this study was to explore the effect of RESVERATROL on the expression of MDR1 gene in LEUKEMIC LYMPHOBLAST of new cases of acute lymphoblastic leukemia (ALL) patients in vitro.Methods: Separation of lymphoblasts of 5 new case ALL patients from peripheral blood was performed by ficoll density gradient centrifugation. Lymphoblasts were cultured in RPMI 1640 medium. Lymphoblasts were treated with 50mmol/L RESVERATROL for 48h. Total RNA was extracted with guanidine isothiocyanate. RNA was converted to cDNA. Real time PCR was used to detect mRNA expression of MDR1.Results: The results of gene detection showed that the expression of MDR1 did not change significantly in the patients however, in one patient expression of MDR1 increased upon treatment with RESVERATROL.Conclusion: The results of this study did not support RESVERATROL as a compound to reverse multidrug resistance in LEUKEMIC LYMPHOBLASTs.

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    APA: Copy

    HOSEINPOOR FEYZI, ABBAS ALI, FARSHDOUSTI HAGH, MAJID, EBADI, TOHID, SHAMS ASANJAN, KARIM, MOVASAGPOOR AKBARI, ALI AKBAR, TALEBI, MEHDI, & EMADI, BEHZAD. (2015). THE EFFECT OF RESVERATROL ON THE EXPRESSION OF MDR1 GENE IN LEUKEMIC LYMPHOBLAST’S OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (SHORT COMMUNICATION). CASPIAN JOURNAL OF INTERNAL MEDICINE, 6(2), 113-115. SID. https://sid.ir/paper/323281/en

    Vancouver: Copy

    HOSEINPOOR FEYZI ABBAS ALI, FARSHDOUSTI HAGH MAJID, EBADI TOHID, SHAMS ASANJAN KARIM, MOVASAGPOOR AKBARI ALI AKBAR, TALEBI MEHDI, EMADI BEHZAD. THE EFFECT OF RESVERATROL ON THE EXPRESSION OF MDR1 GENE IN LEUKEMIC LYMPHOBLAST’S OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (SHORT COMMUNICATION). CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2015;6(2):113-115. Available from: https://sid.ir/paper/323281/en

    IEEE: Copy

    ABBAS ALI HOSEINPOOR FEYZI, MAJID FARSHDOUSTI HAGH, TOHID EBADI, KARIM SHAMS ASANJAN, ALI AKBAR MOVASAGPOOR AKBARI, MEHDI TALEBI, and BEHZAD EMADI, “THE EFFECT OF RESVERATROL ON THE EXPRESSION OF MDR1 GENE IN LEUKEMIC LYMPHOBLAST’S OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS (SHORT COMMUNICATION),” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 6, no. 2, pp. 113–115, 2015, [Online]. Available: https://sid.ir/paper/323281/en

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