Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft

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Vafaey Hamdi Reza; SALEHI OMRAN MOHAMMAD TAGHI; Abbaspour Sadaf; BANIHASHEM NADIA; Faghanzadeh Ganji Ghassem

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Journal Paper

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Journal: Caspian Journal of Internal Medicine Year:2018 | Volume:9 | Issue:1 Page(s): 27-31

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Title

Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft

Author(s)

Keywords

Coronary artery bypass graft

Coronary endarterectomy

Warfarin

Clopidogrel

Abstract

Background: Since there is a lack of research on postoperative anticoagulation protocol in patients undergoing Coronary artery bypass graft (CABG) / Coronary endarterectomy (CE), we recommend a new protocol for anticoagulation in these patients. Methods: In this double-blind randomized clinical trial study, 52 patients undergoing CABG / CE entered the study and were divided into two groups. In group 1, the patients were given Warfarin(international normalized ratio (INR) between 2-3) together with 80 mg aspirin daily for 3 months. In group 2, the patients were given 75 mg plavix daily together with 80 mg aspirin daily for 3 months. We evaluated patients with electrocardiography, echocardiography and checking ceratin phosphokinase MB and troponin I in the several stages. The data were analysed SPSS Version18 software. Results: There was no significant difference between pre and post-operative Ejection fraction in patients with plavix (P=0. 21) and Warfarin (P=0. 316) regimen. However, wall mrotion score was significantly better in Clopidogrel – aspirin patients in late (3 months) post operation (p<0. 001). Conclusions: Since Warfarin has serious hemorrhagic complications and requires closed monitoring of serum drug activity by serial INR checking, it is recommended that Clopidogrel – aspirin can be the preferred alternative anticoagulation therapy in CABG / CE patients.

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APA: Copy

Vafaey, Hamdi Reza, SALEHI OMRAN, MOHAMMAD TAGHI, Abbaspour, Sadaf, BANIHASHEM, NADIA, & Faghanzadeh Ganji, Ghassem. (2018). Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft. CASPIAN JOURNAL OF INTERNAL MEDICINE, 9(1), 27-31. SID. https://sid.ir/paper/323521/en

Vancouver: Copy

Vafaey Hamdi Reza, SALEHI OMRAN MOHAMMAD TAGHI, Abbaspour Sadaf, BANIHASHEM NADIA, Faghanzadeh Ganji Ghassem. Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2018;9(1):27-31. Available from: https://sid.ir/paper/323521/en

IEEE: Copy

Hamdi Reza Vafaey, MOHAMMAD TAGHI SALEHI OMRAN, Sadaf Abbaspour, NADIA BANIHASHEM, and Ghassem Faghanzadeh Ganji, “Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 9, no. 1, pp. 27–31, 2018, [Online]. Available: https://sid.ir/paper/323521/en

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