Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis

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Jafari Nakhjavani Mohammad Reza; GHORBANIHAGHJO AMIR; Bagherzadeh Nobari Babak; MALEK MAHDAVI AIDA; RASHTCHI ZADEH NADEREH

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Journal: Caspian Journal of Internal Medicine Year:2019 | Volume:10 | Issue:1 Page(s): 92-97

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Title

Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis

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Keywords

Rheumatoid arthritis

YKL-40

Disease activity

Abstract

Background: The present study aimed to evaluate serum YKL-40 levels in patients with Rheumatoid arthritis (RA) compared to healthy subjects and to search whether there is an association between YKL-40 levels and disease characteristics in RA. Methods: In this cross-sectional study, 60 RA patients based on the ACR/EULAR 2010 criteria and 30 age-and sex-matched healthy controls were included. In patients, clinical examination was performed and Disease activity score 28 (DAS-28) measure of Disease activity was assessed. Serum YKL-40 level was measured using ELISA kit. Results: The mean± SD age of patients and controls was 54. 86± 11. 65 and 50. 71± 3. 72 years, respectively). Serum YKL-40 level was significantly higher in RA patients (951. 63± 639. 98 pg/mL) compared to healthy controls (444. 92± 150. 37 pg/mL) (P<0. 001). There was no significant difference in serum YKL-40 level according to the activity of disease (p>0. 05). There were significant positive correlations between serum YKL-40 level with Disease activity (r=0. 347, P=0. 007) and rheumatoid factor (r=0. 396, P=0. 002). There were no significant correlations between serum YKL-40 level with demographic characteristics as well as biochemical measurements including serum creatinine, blood urea nitrogen, erythrocyte sedimentation rate, C-reactive protein and anti-cyclic citrullinated peptide. Conclusion: Our study revealed higher serum YKL-40 levels in RA patients compared to healthy controls, which correlated positively with Disease activity. Therefore, YKL-40 can be considered as a novel biomarker for Disease activity estimation in RA.

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APA: Copy

Jafari Nakhjavani, Mohammad Reza, GHORBANIHAGHJO, AMIR, Bagherzadeh Nobari, Babak, MALEK MAHDAVI, AIDA, & RASHTCHI ZADEH, NADEREH. (2019). Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis. CASPIAN JOURNAL OF INTERNAL MEDICINE, 10(1), 92-97. SID. https://sid.ir/paper/323607/en

Vancouver: Copy

Jafari Nakhjavani Mohammad Reza, GHORBANIHAGHJO AMIR, Bagherzadeh Nobari Babak, MALEK MAHDAVI AIDA, RASHTCHI ZADEH NADEREH. Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2019;10(1):92-97. Available from: https://sid.ir/paper/323607/en

IEEE: Copy

Mohammad Reza Jafari Nakhjavani, AMIR GHORBANIHAGHJO, Babak Bagherzadeh Nobari, AIDA MALEK MAHDAVI, and NADEREH RASHTCHI ZADEH, “Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 10, no. 1, pp. 92–97, 2019, [Online]. Available: https://sid.ir/paper/323607/en

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