Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer's disease

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VAKILIAN ALIREZA; MASOUMI JAVAD; MIRZAEE SAEED; KHORRAMDELAZAD HOSSEIN

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Journal Paper

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Journal: Caspian Journal of Internal Medicine Year:2019 | Volume:10 | Issue:3 Page(s): 276-280

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Title

Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer's disease

Author(s)

VAKILIAN ALIREZA | MASOUMI JAVAD | MIRZAEE SAEED | KHORRAMDELAZAD HOSSEIN | Issue Writer Certificate

Keywords

Beta-Site APP-Cleaving Enzyme 1

Alzheimer ’s disease

Biomarker

Abstract

Background: Recent evidence has indicated that beta-secretase 1 (BACE1) is involved in the production of amyloid beta (Aβ ) in patients affected with Alzheimer’ s disease (AD). Therefore; the purpose of this study was to measure mRNA and plasma levels of BACE1 in AD patients, as an early diagnosis Biomarker for such individuals. Methods: A total number of thirty AD patients and thirty normal subjects as controls were recriuted in the present study. Plasma levels of BACE1 were then examined via enzymelinked immunosorbent assay (ELISA) and also mRNA expression of BACE1 in total blood was measured using real-time PCR technique. Results: The findings revealed a significant difference in gene expression of BACE1 in the peripheral blood of AD patients compared with that in controls (p<0. 0001). Additionally, elevated plasma levels of BACE1 were found in AD patients compared with those in normal subjects (p<0. 01). Statistical analyses also demonstrated no correlation between expression (mRNA and protein) of BACE1 in both AD patients and controls and age or the results of Mini-Mental State Examination (MMSE) scale (p>0. 05). Conclusion: Given the importance of early diagnosis of AD patients, it was suggested that the measurement of plasma levels and also mRNA expression of BACE1 might be a valuable blood-based Biomarker used in preference to other invasive diagnostic methods such as cerebrospinal fluid (CSF) analysis.

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APA: Copy

VAKILIAN, ALIREZA, MASOUMI, JAVAD, MIRZAEE, SAEED, & KHORRAMDELAZAD, HOSSEIN. (2019). Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer's disease. CASPIAN JOURNAL OF INTERNAL MEDICINE, 10(3), 276-280. SID. https://sid.ir/paper/323614/en

Vancouver: Copy

VAKILIAN ALIREZA, MASOUMI JAVAD, MIRZAEE SAEED, KHORRAMDELAZAD HOSSEIN. Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer's disease. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2019;10(3):276-280. Available from: https://sid.ir/paper/323614/en

IEEE: Copy

ALIREZA VAKILIAN, JAVAD MASOUMI, SAEED MIRZAEE, and HOSSEIN KHORRAMDELAZAD, “Expression analysis of beta-secretase 1 (BACE1) enzyme in peripheral blood of patients with Alzheimer's disease,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 10, no. 3, pp. 276–280, 2019, [Online]. Available: https://sid.ir/paper/323614/en

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