The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency

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Haj hashemi Maryam; ANSARI MARYAM; HAGHOLLAHI FEDYEH; ESLAMI BITA

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Journal: Caspian Journal of Internal Medicine Year:2019 | Volume:10 | Issue:2 Page(s): 125-131

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Title

The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency

Author(s)

Haj hashemi Maryam | ANSARI MARYAM | HAGHOLLAHI FEDYEH | ESLAMI BITA | Issue Writer Certificate

Keywords

Uterine leiomyomas

25-hydroxyvitamin D3

Vitamin D deficiency

Abstract

Background: Uterine leiomyomas (fibroids) are the most common benign pelvic tumors in women of reproductive age with an incidence ranging from 5. 4% to 77%, Also, there is a high prevalence of vit D deficiency in Iran and there are the numbers of in vivo and vitro biological studies on the relationship of vitamin D and Uterine leiomyomas. The aim of this study was to evaluate the effect of vit D supplementation on the size of uterine leiomyoma in women with vit D deficiency. Methods: This double-blind prospective clinical trial was performed on 69 patients with Uterine leiomyomas who had vit D deficiency. Group A (n=35) was treated with vit D 50, 000 IU every 2 weeks for 10 weeks, while group B (n=34) received placebo with same color and shape. Finally, the leiomyoma size in both groups was compared (IRCT: 20160521027998N5). Results: After a 10-week intervention, 25-hydroxyvitamin D3 levels were significantly higher in group receiving vitamin D (36. 08 vs 16. 25 ng/ml). (P<0. 001) Leiomyomas size in vit D group significantly decreased as compared to placebo group (52. 58 vs 61. 11 mm, respectively). Conclusion: Our results showed that administration of vit D3 may reduce the size of leiomyoma. It seems that vitamin D administration is the effective way to treat leiomyoma.

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APA: Copy

Haj hashemi, Maryam, ANSARI, MARYAM, HAGHOLLAHI, FEDYEH, & ESLAMI, BITA. (2019). The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency. CASPIAN JOURNAL OF INTERNAL MEDICINE, 10(2), 125-131. SID. https://sid.ir/paper/323650/en

Vancouver: Copy

Haj hashemi Maryam, ANSARI MARYAM, HAGHOLLAHI FEDYEH, ESLAMI BITA. The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2019;10(2):125-131. Available from: https://sid.ir/paper/323650/en

IEEE: Copy

Maryam Haj hashemi, MARYAM ANSARI, FEDYEH HAGHOLLAHI, and BITA ESLAMI, “The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 10, no. 2, pp. 125–131, 2019, [Online]. Available: https://sid.ir/paper/323650/en

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