New formulation of ibuprofen on absorption-rate: A comparative bioavailability study in healthy volunteers

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Moghadamnia Yasamin; KAZEMI SOHRAB; Rezaee Boshra; RAFATI RAHIMZADEH MEHRDAD; EBRAHIMPOUR SOHEIL; Aghapour Fahimeh

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Journal: Caspian Journal of Internal Medicine Year:2019 | Volume:10 | Issue:2 Page(s): 150-155

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Title

New formulation of ibuprofen on absorption-rate: A comparative bioavailability study in healthy volunteers

Author(s)

Keywords

Ibuprofen

Pharmacokinetics

COX2-inhibitory effects

Abstract

Background: Enteric-coated capsules are solid dosage forms which are designed to bypass the stomach and release the drug in the small intestine. This study was done to compare Pharmacokinetics of Ibuprofen tablet and Ibuprofen as enteric-coated capsule using sodium alginate beads. Methods: A crossover randomized study was performed on 12 healthy volunteers receiving a single dose of regular Ibuprofen tablet (200 mg) and enteric-coated capsule (200 mg). The washout time between the periods was one month. Pharmacokinetic and pharmacodynamic blood samples were collected for 16 hours following treatment. Highperformance liquid chromatography (HPLC) method used the following specifications: C18 column with 4. 6 mm diameter & 25 mm length, the fluorescent detector of excitation and emission wavelengths were 224 and 290 nm, respectively. Results: After a single oral dose of Ibuprofen formulations, the median times to maximum concentration were 60 and 240 minutes in Ibuprofen tablet (200 mg) and enteric-coated capsule, respectively. The maximum levels for the participants receiving Ibuprofen tablet and enteric-coated capsule were 11. 71± 1. 3 and 10. 32± 4. 19 μ g/mL, respectively. The pharmacokinetic (PK) modeling data showed the area under curve (AUC) to be 61. 51 hours & 86. 62 hours for the group receiving the tablet and the capsule, respectively. Conclusion: According to the results, in is concluded that enteric coating may delay the onset of Ibuprofen effect and increases the duration of action. This formulation has advantages over the conventional drug delivery systems as it lengthens the dosing intervals and also increases patient compliance for chronic pain.

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References

Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

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APA: Copy

Moghadamnia, Yasamin, KAZEMI, SOHRAB, Rezaee, Boshra, RAFATI RAHIMZADEH, MEHRDAD, EBRAHIMPOUR, SOHEIL, & Aghapour, Fahimeh. (2019). New formulation of ibuprofen on absorption-rate: A comparative bioavailability study in healthy volunteers. CASPIAN JOURNAL OF INTERNAL MEDICINE, 10(2), 150-155. SID. https://sid.ir/paper/323651/en

Vancouver: Copy

Moghadamnia Yasamin, KAZEMI SOHRAB, Rezaee Boshra, RAFATI RAHIMZADEH MEHRDAD, EBRAHIMPOUR SOHEIL, Aghapour Fahimeh. New formulation of ibuprofen on absorption-rate: A comparative bioavailability study in healthy volunteers. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2019;10(2):150-155. Available from: https://sid.ir/paper/323651/en

IEEE: Copy

Yasamin Moghadamnia, SOHRAB KAZEMI, Boshra Rezaee, MEHRDAD RAFATI RAHIMZADEH, SOHEIL EBRAHIMPOUR, and Fahimeh Aghapour, “New formulation of ibuprofen on absorption-rate: A comparative bioavailability study in healthy volunteers,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 10, no. 2, pp. 150–155, 2019, [Online]. Available: https://sid.ir/paper/323651/en

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