SPONTANEOUS RESOLUTION OF VESICOURETERAL REFLUX (VUR) IN IRANIAN CHILDREN: A SINGLE CENTER EXPERIENCE IN 533 CASES

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SHARIFIAN MOSTAFA; ZINSAZ BOROUJERDI HAMED; DALIRANI REZA; MAHAM SAEED; AKHAVAN SEPAHI MOHSEN; KARIMI ABDOLLAH; GHAFFARI SHAD MARYAM; DADKHAH CHYMEH MASOUD; SHARIFIAN MARYAM

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Journal: Nephro-Urology Monthly Year:2011 | Volume:3 | Issue:3 (9) Page(s): 191-195

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Title

SPONTANEOUS RESOLUTION OF VESICOURETERAL REFLUX (VUR) IN IRANIAN CHILDREN: A SINGLE CENTER EXPERIENCE IN 533 CASES

Author(s)

Keywords

URINARY TRACT INFECTION

VESICO-URETERAL REFLUX

CHILD

Abstract

Background: Experience with vesicoureteral reflux (VUR) resolution differs in different centers.Objective: The aim of this study was to evaluate the epidemiologic characteristics and outcome of VUR among Iranian CHILDren.Patients and Methods: In this cohort study, 1278 CHILDren with URINARY TRACT INFECTION (UTI) who were visited at the pediatric nephrology clinic; Tehran, IR Iran during 1999 to 2007 were studied. Following the diagnosis, patients received prophylactic low-dose oral antibiotic and one to two yearly follow-ups with Radionuclide Cystography (RNC). Patients underwent surgery in case of breakthrough infection or new renal scar formation.Results: Vesicoureteral reflux was found in 533 patients (42%) with a mean age of 6.3 ± 3.6 years (Range 2 days to 18 years), out of which 436 (82%) were females. During 3.3 ± 2.2 years follow-up, spontaneous resolution was observed in 109 (39%) of 279 patients with follow-up RNCs. Mean time to spontaneous resolution was 1.5 ± 1 years. Frequencies of VUR grades at initial investigation were 18%, 37%, 26%, 11% and 8% for grades I to V respectively, and 46% had bilateral VUR. Grades I to V resolved in 63%, 57%, 27%, 22% and 10%, respectively. Anti reflux surgery was performed in 27 (10%) of patients. Two handred fourty nine patients proceeded to follow-up with Dimercaptosuccinic acid (DMSA) scan. There were 4 (4%) renal scars in patients with spontaneous resolution and 8 (5%) renal scars in patients without spontaneous resolution of VUR (P >0.05).Conclusions: According to the excellent results with medical therapy, it is recommended that VUR grades 1 to 4 be managed medically with low-dose antibiotic prophylaxis and close follow-ups.

Cites

ANALYSIS OF THE IL-10, IL-12, AND TNF-α GENE POLYMORPHISMS IN PATIENTS WITH VESICOURETERAL REFLUX AMONG THE SOUTHEAST IRANIAN POPULATION

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APA: Copy

SHARIFIAN, MOSTAFA, ZINSAZ BOROUJERDI, HAMED, DALIRANI, REZA, MAHAM, SAEED, AKHAVAN SEPAHI, MOHSEN, KARIMI, ABDOLLAH, GHAFFARI SHAD, MARYAM, DADKHAH CHYMEH, MASOUD, & SHARIFIAN, MARYAM. (2011). SPONTANEOUS RESOLUTION OF VESICOURETERAL REFLUX (VUR) IN IRANIAN CHILDREN: A SINGLE CENTER EXPERIENCE IN 533 CASES. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 3(3 (9)), 191-195. SID. https://sid.ir/paper/323688/en

Vancouver: Copy

SHARIFIAN MOSTAFA, ZINSAZ BOROUJERDI HAMED, DALIRANI REZA, MAHAM SAEED, AKHAVAN SEPAHI MOHSEN, KARIMI ABDOLLAH, GHAFFARI SHAD MARYAM, DADKHAH CHYMEH MASOUD, SHARIFIAN MARYAM. SPONTANEOUS RESOLUTION OF VESICOURETERAL REFLUX (VUR) IN IRANIAN CHILDREN: A SINGLE CENTER EXPERIENCE IN 533 CASES. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2011;3(3 (9)):191-195. Available from: https://sid.ir/paper/323688/en

IEEE: Copy

MOSTAFA SHARIFIAN, HAMED ZINSAZ BOROUJERDI, REZA DALIRANI, SAEED MAHAM, MOHSEN AKHAVAN SEPAHI, ABDOLLAH KARIMI, MARYAM GHAFFARI SHAD, MASOUD DADKHAH CHYMEH, and MARYAM SHARIFIAN, “SPONTANEOUS RESOLUTION OF VESICOURETERAL REFLUX (VUR) IN IRANIAN CHILDREN: A SINGLE CENTER EXPERIENCE IN 533 CASES,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 3, no. 3 (9), pp. 191–195, 2011, [Online]. Available: https://sid.ir/paper/323688/en

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