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Information Journal Paper

Title

REVERSED CLINICAL AND MORPHOLOGIC CHARACTERISTICS OF IDIOPATHIC CHILDHOOD NEPHROTIC SYNDROME

Pages

  200-211

Abstract

 Background and Aims: Minimal change disease (MCD) is uncommon in Nigeria; in the sixties and eighties quartan malaria nephropathy accounted for more than 80.0% of all cases of childhood nephrotic syndrome (CNS). There is paucity of current clinical and morphologic data on CNS. This study therefore determined the incidence and prevalence of CNS, pre-treatment glomerular pathology of idiopathic CNS (ICNS), renal and patient outcome in steroid sensitive ICNS.Methods: A non-randomized prospective study of consecutive cases of Nigerian children with idiopathic nephrotic syndrome was conducted over a 9-year period.Results: CNS accounted for 1.26% of pediatric admissions. Fifty-four of 78 (69.2%) nephrotic children had ICNS (incidence, 0.44/100000/year). Median NS onset age was 7.1 (2.5-14.0) years. Male: female ratio was 1.7. The histopathologic lesions were membranoproliferative glomerulonephritis (MPGN, 44.4%), focal segmental glomerulosclerosis (FSGS, 25.9%), MCD (18.5%), mesangial proliferative glomerulonephritis (7.4%) and membranous nephropathy (3.7%). Overall cumulative complete REMISSION (CR) rate 4 to 8 weeks post prednisolone treatment was 49.6%. Twenty-two of 25 with CR were early steroid responders while 3 were late responders. Median time to CR was 12.0 (3.0-46.0) days. Thirty RELAPSEs occurred; median time to first RELAPSE was 11.0 months. Cumulative five-year RELAPSE-free rate was 26.6%. Five-year renal survival was 16.1%. All patients with CR were followed-up for 6-93 (median, 22.0) months.Conclusions: Prevalence of non-MCD was very high with significant resistance to prednisolone; poor renal survival was due to high frequency of MPGN and FSGS. Pre-treatment renal biopsy is advocated in our kind of patients so that steroid-sparing agents can be started early.

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    APA: Copy

    OLOWU, WASIU A., ADELUSOLA, KAYODE A., & ADEFEHINTI, OLUFEMI. (2010). REVERSED CLINICAL AND MORPHOLOGIC CHARACTERISTICS OF IDIOPATHIC CHILDHOOD NEPHROTIC SYNDROME. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 2(1), 200-211. SID. https://sid.ir/paper/323746/en

    Vancouver: Copy

    OLOWU WASIU A., ADELUSOLA KAYODE A., ADEFEHINTI OLUFEMI. REVERSED CLINICAL AND MORPHOLOGIC CHARACTERISTICS OF IDIOPATHIC CHILDHOOD NEPHROTIC SYNDROME. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2010;2(1):200-211. Available from: https://sid.ir/paper/323746/en

    IEEE: Copy

    WASIU A. OLOWU, KAYODE A. ADELUSOLA, and OLUFEMI ADEFEHINTI, “REVERSED CLINICAL AND MORPHOLOGIC CHARACTERISTICS OF IDIOPATHIC CHILDHOOD NEPHROTIC SYNDROME,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 2, no. 1, pp. 200–211, 2010, [Online]. Available: https://sid.ir/paper/323746/en

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