IMPACT OF DONOR SOURCE ON THE OUTCOME OF LIVE DONOR KIDNEY TRANSPLANTATION: A SINGLE CENTER EXPERIENCE

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ELSAYED MATTER YASSER; NAGIB AYMAN M.; LOTFY OMAR E.; ALSAYED AHMED MAHER; DONIA AHMED F.; REFAIE AYMAN F.; AKL AHMED I.; ABBAS MOHAMED HAMED; ABUELMAGD MOHAMMED M.; SHAEASHAA HUSSEIN A.; SHOKEIR AHMED A.

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Journal: Nephro-Urology Monthly Year:2016 | Volume:8 | Issue:3 Page(s): 0-0

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Title

IMPACT OF DONOR SOURCE ON THE OUTCOME OF LIVE DONOR KIDNEY TRANSPLANTATION: A SINGLE CENTER EXPERIENCE

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Keywords

KIDNEY TRANSPLANTATION

LIVE-DONOR

CONSANGUINITY

Abstract

Background: Renal transplantation is the ideal method for management of end-stage renal disease. The use of living donors for renal transplantation was critical for early development in the field and preceded the use of cadaveric donors. Most donors are related genetically to the recipients, like a parent, a child, or a sibling of the recipient, but there are an increasing percentage of cases where donors are genetically unrelated like spouses, friends, or altruistic individuals. Donor shortages constitute the major barrier for KIDNEY TRANSPLANTATION, and much effort has been made to increase the supply of living donors. The impact of donor source on the outcome of renal transplantation is not adequately studied in our country.Objectives: The aim of the study was to evaluate the impact of donor source on the outcome of live donor KIDNEY TRANSPLANTATION.Patients and Methods: From March 1976 to December 2013, the number of patients that underwent living renal transplantation sharing at least one HLA haplotype with their donors was 2, 485. We divided these patients into two groups: (1) 2, 075 kidney transplant recipients (1, 554 or 74.9% male and 521 or 25.1% female) for whom the donors were living related, (2) 410 kidney transplant recipients (297 or 72.4% male and 113 or 27.6% female) for whom the donors were living unrelated. All patients received immunosuppressive therapy, consisting of a calcineurin inhibitor, mycophenolate mofetil, or azathioprine and prednisolone. We compared acute rejection and complication rates, as well as long-term graft and patient survival of both groups. Demographic characteristics were compared using the chi-square test. Graft survival and patient survival were calculated using the Kaplan-Meier method.Results: The percentages of patients with acute vascular rejection were significantly higher in the unrelated group, while percentages of patients with no rejection were significantly higher in the related group, but there were no significant differences regarding patient and graft survivals between both groups.Conclusions: Kidney transplant recipients who received their grafts either from live related donors or live unrelated donors had comparable patient and graft survival outcomes.

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APA: Copy

ELSAYED MATTER, YASSER, NAGIB, AYMAN M., LOTFY, OMAR E., ALSAYED, AHMED MAHER, DONIA, AHMED F., REFAIE, AYMAN F., AKL, AHMED I., ABBAS, MOHAMED HAMED, ABUELMAGD, MOHAMMED M., SHAEASHAA, HUSSEIN A., & SHOKEIR, AHMED A.. (2016). IMPACT OF DONOR SOURCE ON THE OUTCOME OF LIVE DONOR KIDNEY TRANSPLANTATION: A SINGLE CENTER EXPERIENCE. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 8(3), 0-0. SID. https://sid.ir/paper/323779/en

Vancouver: Copy

ELSAYED MATTER YASSER, NAGIB AYMAN M., LOTFY OMAR E., ALSAYED AHMED MAHER, DONIA AHMED F., REFAIE AYMAN F., AKL AHMED I., ABBAS MOHAMED HAMED, ABUELMAGD MOHAMMED M., SHAEASHAA HUSSEIN A., SHOKEIR AHMED A.. IMPACT OF DONOR SOURCE ON THE OUTCOME OF LIVE DONOR KIDNEY TRANSPLANTATION: A SINGLE CENTER EXPERIENCE. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2016;8(3):0-0. Available from: https://sid.ir/paper/323779/en

IEEE: Copy

YASSER ELSAYED MATTER, AYMAN M. NAGIB, OMAR E. LOTFY, AHMED MAHER ALSAYED, AHMED F. DONIA, AYMAN F. REFAIE, AHMED I. AKL, MOHAMED HAMED ABBAS, MOHAMMED M. ABUELMAGD, HUSSEIN A. SHAEASHAA, and AHMED A. SHOKEIR, “IMPACT OF DONOR SOURCE ON THE OUTCOME OF LIVE DONOR KIDNEY TRANSPLANTATION: A SINGLE CENTER EXPERIENCE,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 8, no. 3, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/323779/en

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