FREQUENCY AND ASSOCIATED FACTORS OF AMPHOTERICIN B NEPHROTOXICITY IN HOSPITALIZED PATIENTS IN HEMATOLOGY-ONCOLOGYWARDS IN THE SOUTHWEST OF IRAN

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KARIMZADEH IMAN; HEYDARI MARZIYEH; RAMZI MANI; SAGHEB MOHAMMAD MAHDI

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Journal: Nephro-Urology Monthly Year:2016 | Volume:8 | Issue:5 Page(s): 0-0

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Title

FREQUENCY AND ASSOCIATED FACTORS OF AMPHOTERICIN B NEPHROTOXICITY IN HOSPITALIZED PATIENTS IN HEMATOLOGY-ONCOLOGYWARDS IN THE SOUTHWEST OF IRAN

Author(s)

KARIMZADEH IMAN | HEYDARI MARZIYEH | RAMZI MANI | SAGHEB MOHAMMAD MAHDI | Issue Writer Certificate

Keywords

AMPHOTERICIN B

NEPHROTOXICITY

HEMATOLOGY-ONCOLOGY

INCIDENCE

ASSOCIATED FACTORS

Abstract

Background: NEPHROTOXICITY is the most clinically significant adverse reaction of AMPHOTERICIN B. Different aspects of AMPHOTERICIN B (AmB) NEPHROTOXICITY have not been studied well in our population.Objectives: The purpose of this study was to assess the frequency, time onset, and possible ASSOCIATED FACTORS of AmBnephrotoxicity in hospitalized patients in HEMATOLOGY-ONCOLOGY wards in the southwest of Iran.Patients and Methods: A cross-sectional, observational study was performed over a period of 9 months at 2 HEMATOLOGY-ONCOLOGY and 1 hematopoietic stem cell transplantation wards at Namazi Hospital. Patients aged 15 years or older with nodocumented history of acute kidney injury or chronic kidney disease who were scheduled to receive formulations of AmB intravenously for at least 1 week were included. The required demographic and clinical data of the patients were recorded. Urine urea, creatinine, sodium, potassium, and magnesium levels were measured at days 0, 3, 5, 7, 10, and 14 of the AmB treatment. AmB NEPHROTOXICITY based on serum creatinine increase, renal potassium wasting, hypokalemia, and hypomagnesemia were determined.Results: Amongthe40patients recruited for the study, 11 (27.5%) patients developed AmB NEPHROTOXICITY with amean±standard deviation onset of 6.73±2.36 days. In 5 patients, AmB NEPHROTOXICITY resolved spontaneously without any intervention. According to the multivariate logistic regression model, none of the studied demographic, clinical, and paraclinical variables were significantly associated with AmB NEPHROTOXICITY. The duration of hospitalization (P=0.541) and the mortality rate (P=0.723) were comparable between the patients with and without AmB NEPHROTOXICITY. Hypokalemia and renal potassium wasting were identified in 45% and 27.5% of the patients during AmB treatment, respectively.Conclusions: Nearly one-third (27.5%) of our cohort developed NEPHROTOXICITY within the first week of AmB vtreatment. Hypokalemia and renal potassium wasting were more notable, affecting about one-third and one-half of the AmB recipients, respectively.

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APA: Copy

KARIMZADEH, IMAN, HEYDARI, MARZIYEH, RAMZI, MANI, & SAGHEB, MOHAMMAD MAHDI. (2016). FREQUENCY AND ASSOCIATED FACTORS OF AMPHOTERICIN B NEPHROTOXICITY IN HOSPITALIZED PATIENTS IN HEMATOLOGY-ONCOLOGYWARDS IN THE SOUTHWEST OF IRAN. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 8(5), 0-0. SID. https://sid.ir/paper/323825/en

Vancouver: Copy

KARIMZADEH IMAN, HEYDARI MARZIYEH, RAMZI MANI, SAGHEB MOHAMMAD MAHDI. FREQUENCY AND ASSOCIATED FACTORS OF AMPHOTERICIN B NEPHROTOXICITY IN HOSPITALIZED PATIENTS IN HEMATOLOGY-ONCOLOGYWARDS IN THE SOUTHWEST OF IRAN. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2016;8(5):0-0. Available from: https://sid.ir/paper/323825/en

IEEE: Copy

IMAN KARIMZADEH, MARZIYEH HEYDARI, MANI RAMZI, and MOHAMMAD MAHDI SAGHEB, “FREQUENCY AND ASSOCIATED FACTORS OF AMPHOTERICIN B NEPHROTOXICITY IN HOSPITALIZED PATIENTS IN HEMATOLOGY-ONCOLOGYWARDS IN THE SOUTHWEST OF IRAN,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 8, no. 5, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/323825/en

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