MYOCARDIAL INJURY IS DECREASED BY LATE REMOTE ISCHAEMIC PRECONDITIONING AND AGGRAVATED BY TRAMADOL IN PATIENTS UNDERGOING CARDIAC SURGERY: A RANDOMISED CONTROLLED TRIAL

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BAGHAEI R.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF CARDIAC SURGERY Year:2011 | Volume:3 | Issue:1 Page(s): 47-47

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Title

MYOCARDIAL INJURY IS DECREASED BY LATE REMOTE ISCHAEMIC PRECONDITIONING AND AGGRAVATED BY TRAMADOL IN PATIENTS UNDERGOING CARDIAC SURGERY: A RANDOMISED CONTROLLED TRIAL

Author(s)

BAGHAEI R.

Keywords

MYOCARDIAL PROTECTION

ISCHAEMIC PRECONDITIONING

TROPONIN I

INDUCIBLE NITRIC OXIDE SYNTHASES

ENDOTHELIAL NITRIC OXIDE SYNTHASES

Abstract

The purpose of this study was to test, whether the late phase of remote ISCHAEMIC PRECONDITIONING (L-RIPC) improves MYOCARDIAL PROTECTION in coronary artery bypass grafting (CABG) with cold-crystalloid cardioplegia and whether preoperative tramadol modifies myocardial ischaemia–reperfusion injury using the same group of patients in a singleblinded randomized controlled study. One hundred and one adult patients were randomly assigned to either the L-RIPC, control or tramadol group. L-RIPC consisted of three fiveminute cycles of upper limb ischaemia and three five-minute pauses using blood pressure cuff inflation 18 hours prior to the operation. Patients in the tramadol group received 200 mg tramadol retard at 19:00 hours, the day before theoperation and at 06:00 hours. Serum TROPONIN I levels were measured at eight, 16 and 24 hours after surgery. Myocardial samples for inducible and ENDOTHELIAL NITRIC OXIDE SYNTHASES (iNOS, eNOS) estimation were drawn twice: before and after cannulation for cardiopulmonary bypass from the auricle of the right atrium. We found that L-RIPC canreduce injury beyond the MYOCARDIAL PROTECTION provided by cold-crystalloid cardioplegia, and tramadol worsened myocardial injury after CABG. Expressions of iNOS were increased in the control (significantly) and L-RIPC groups and dampened in the tramadol group.

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APA: Copy

BAGHAEI, R.. (2011). MYOCARDIAL INJURY IS DECREASED BY LATE REMOTE ISCHAEMIC PRECONDITIONING AND AGGRAVATED BY TRAMADOL IN PATIENTS UNDERGOING CARDIAC SURGERY: A RANDOMISED CONTROLLED TRIAL. IRANIAN JOURNAL OF CARDIAC SURGERY, 3(1), 47-47. SID. https://sid.ir/paper/324122/en

Vancouver: Copy

BAGHAEI R.. MYOCARDIAL INJURY IS DECREASED BY LATE REMOTE ISCHAEMIC PRECONDITIONING AND AGGRAVATED BY TRAMADOL IN PATIENTS UNDERGOING CARDIAC SURGERY: A RANDOMISED CONTROLLED TRIAL. IRANIAN JOURNAL OF CARDIAC SURGERY[Internet]. 2011;3(1):47-47. Available from: https://sid.ir/paper/324122/en

IEEE: Copy

R. BAGHAEI, “MYOCARDIAL INJURY IS DECREASED BY LATE REMOTE ISCHAEMIC PRECONDITIONING AND AGGRAVATED BY TRAMADOL IN PATIENTS UNDERGOING CARDIAC SURGERY: A RANDOMISED CONTROLLED TRIAL,” IRANIAN JOURNAL OF CARDIAC SURGERY, vol. 3, no. 1, pp. 47–47, 2011, [Online]. Available: https://sid.ir/paper/324122/en

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