مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

DIAZINON-INDUCED OVARIAN TOXICITY AND PROTECTION BY VITAMINS E

Pages

  1130-1135

Abstract

 Background: DZN (DIAZINON) is an organophosphate insecticide that had been used in agriculture and for domestic and veterinary use for several years and caused many negative effects on plants and animal species, especially on human. The aim of present study was to evaluate the effects of DZN on MDA (malondialdehyde) and GSH (glutathione) levels in female rat reproductive tissue (ovary) and to assess the protective role of VITAMIN E.Methods: A total of 30 adult female Wistar rats were divided into five groups: control group (without any intervention), sham group (received only pure corn oil, as solvent), experimental group 1 (DZN+corn oil, 60 mg/kg), experimental group 2 (vitamin E, 200 mg/kg), and experimental group 3 (DZN+vitamin E, the same dosage). All drugs were injected intraperitoneally, except VITAMIN E which was administrated by gavage. The animals were scarified after two weeks and MDA as a marker of lipid peroxidation and GSH content were measured in ovarian tissue.Results: DZN reduced GSH content and increased MDA level in OVARY compared with the control group (P<0.001). VITAMIN E plus DZN increased GSH content but decreased DZNinduced MDA elevation in rat ovarian tissue.Conclusion: Oxidative stress contributes to DZN-induced ovarian toxicity. The results of this study suggested that VITAMIN E may have a protective effect on DZN-induced ovarian toxicity.

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    APA: Copy

    SARGAZI, ZINAT, NIKRAVESH, MOHAMMAD REZA, JALALI, MEHDI, SADEGHNIA, HAMID REZA, RAHIMI ANBARKEH, FATEMEH, & MOHAMMADZADEH, LEILA. (2014). DIAZINON-INDUCED OVARIAN TOXICITY AND PROTECTION BY VITAMINS E. IRANIAN JOURNAL OF TOXICOLOGY, 8(26), 1130-1135. SID. https://sid.ir/paper/324329/en

    Vancouver: Copy

    SARGAZI ZINAT, NIKRAVESH MOHAMMAD REZA, JALALI MEHDI, SADEGHNIA HAMID REZA, RAHIMI ANBARKEH FATEMEH, MOHAMMADZADEH LEILA. DIAZINON-INDUCED OVARIAN TOXICITY AND PROTECTION BY VITAMINS E. IRANIAN JOURNAL OF TOXICOLOGY[Internet]. 2014;8(26):1130-1135. Available from: https://sid.ir/paper/324329/en

    IEEE: Copy

    ZINAT SARGAZI, MOHAMMAD REZA NIKRAVESH, MEHDI JALALI, HAMID REZA SADEGHNIA, FATEMEH RAHIMI ANBARKEH, and LEILA MOHAMMADZADEH, “DIAZINON-INDUCED OVARIAN TOXICITY AND PROTECTION BY VITAMINS E,” IRANIAN JOURNAL OF TOXICOLOGY, vol. 8, no. 26, pp. 1130–1135, 2014, [Online]. Available: https://sid.ir/paper/324329/en

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