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Information Journal Paper

Title

IN VITRO ANTIMICROBIAL ACTIVITY OF NEW SUBSTITUTED PHENYLTHIAZOLE DERIVATIVES

Pages

  33-37

Abstract

 Background: In this study, we evaluated antibacterial and antifungle activity of these derivatives against gram positive (Staphylococcus aureus, Bacillus subtilis, B. cereus), gram negative (Proteus vulgaris) bacteria and fungale (Candida albicans, C. tropicalis and C. glabrata).Methods: The broth macro dilution and well agar diffusion methods were used for determination of inhibition zoom (IZ) and MINIMUM INHIBITORY CONCENTRATION (MIC) during preliminary evaluation of ANTIMICROBIAL ACTIVITY.Results: The (MIC) values of tested compounds revealed that all compounds were active against Staphylococcus oureusand exhibited the same antibacterial activity in comparison to ceftizoxim (MIC=125mg/mL). The results of antifungal screening showed that all the compounds were potent ANTIMICROBIAL ACTIVITY against tested pathogenic fungi (MIC=250 to1000 mg/ml). Compounds (6a) and (6b) showed the maximum activity with MIC value of 250 mg/ml against all tested fungi, but compound (6h) showed poor antifungal activity against all fungi. MIC values for title compounds were similar to MIC results for fluconazol.Conclusions: All the compounds are potent antifungal and antibacterial activity against tested microorganism.

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    Cite

    APA: Copy

    KOUHKAN, MARYAM, SOULDOZI, ALI, & TALEBI, REZA. (2018). IN VITRO ANTIMICROBIAL ACTIVITY OF NEW SUBSTITUTED PHENYLTHIAZOLE DERIVATIVES. IRANIAN JOURNAL OF TOXICOLOGY, 12(1), 33-37. SID. https://sid.ir/paper/324448/en

    Vancouver: Copy

    KOUHKAN MARYAM, SOULDOZI ALI, TALEBI REZA. IN VITRO ANTIMICROBIAL ACTIVITY OF NEW SUBSTITUTED PHENYLTHIAZOLE DERIVATIVES. IRANIAN JOURNAL OF TOXICOLOGY[Internet]. 2018;12(1):33-37. Available from: https://sid.ir/paper/324448/en

    IEEE: Copy

    MARYAM KOUHKAN, ALI SOULDOZI, and REZA TALEBI, “IN VITRO ANTIMICROBIAL ACTIVITY OF NEW SUBSTITUTED PHENYLTHIAZOLE DERIVATIVES,” IRANIAN JOURNAL OF TOXICOLOGY, vol. 12, no. 1, pp. 33–37, 2018, [Online]. Available: https://sid.ir/paper/324448/en

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