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Information Journal Paper

Title

THE RELATION BETWEEN THE LEVEL OF INTERLEUKIN-23 WITH DURATION AND SEVERITY OF ULCERATIVE COLITIS

Pages

  49-53

Abstract

 Aim: In this study, we determined the relationship between the serum level of IL-23 and the severity of ULCERATIVE COLITIS (UC) among our population.Background: A recent major breakthrough for describing the pathogenesis of intestinal tissue injury in inflammatory bowel disease (IBD) is the pathway related to interleukin-23 (IL-23).Patients and methods: We performed a prospective case-control study on a total of 85 new patients with ULCERATIVE COLITIS, recruited from a general referral hospital. Forty ethnically matched healthy controls were also enrolled among hospital staffs and analyzed. Serum IL-23 level was quantified using an electrochemiluminescence immunoassay (ECLIA) method with an immunoassay analyzer.Results: The mean serum IL-23 level in the group with ULCERATIVE COLITIS was significantly higher than the healthy individuals (347.5±130.8 pg/ml versus 233.5±86.3 pg/ml, p<0.001). There was a positive correlation between the serum level of IL-23 and disease duration (r=0.27, p=0.04). Also, a direct relationship was found between the serum level of IL-23 and the SEVERITY OF DISEASE (mean IL-23 in mild UC=296.2±51.2 pg/ml, in moderate UC=356.1±142.9 pg/ml, and in severe UC=399.3±163.8 pg/ml, p=0.04).Conclusion: Serum level of IL-23 is directly correlated with the duration and severity of ULCERATIVE COLITIS.

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    APA: Copy

    MIRSATTARI, DARIUSH, SEYYEDMAJIDI, MOHAMMADREZA, ZOJAJI, HOMAYOUN, HAGHAZALI, MEHRDAD, GOORAN ORIMI, PEYMAN, SHOUSHTARIZADEH, TINA, & ALMASI, SHOHREH. (2012). THE RELATION BETWEEN THE LEVEL OF INTERLEUKIN-23 WITH DURATION AND SEVERITY OF ULCERATIVE COLITIS. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 5(1), 49-53. SID. https://sid.ir/paper/324556/en

    Vancouver: Copy

    MIRSATTARI DARIUSH, SEYYEDMAJIDI MOHAMMADREZA, ZOJAJI HOMAYOUN, HAGHAZALI MEHRDAD, GOORAN ORIMI PEYMAN, SHOUSHTARIZADEH TINA, ALMASI SHOHREH. THE RELATION BETWEEN THE LEVEL OF INTERLEUKIN-23 WITH DURATION AND SEVERITY OF ULCERATIVE COLITIS. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2012;5(1):49-53. Available from: https://sid.ir/paper/324556/en

    IEEE: Copy

    DARIUSH MIRSATTARI, MOHAMMADREZA SEYYEDMAJIDI, HOMAYOUN ZOJAJI, MEHRDAD HAGHAZALI, PEYMAN GOORAN ORIMI, TINA SHOUSHTARIZADEH, and SHOHREH ALMASI, “THE RELATION BETWEEN THE LEVEL OF INTERLEUKIN-23 WITH DURATION AND SEVERITY OF ULCERATIVE COLITIS,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 5, no. 1, pp. 49–53, 2012, [Online]. Available: https://sid.ir/paper/324556/en

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