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Information Journal Paper

Title

EFFECT OF VITAMIN D3 SUPPLEMENTATION ON TNF-α SERUM LEVEL AND DISEASE ACTIVITY INDEX IN IRANIAN IBD PATIENTS

Pages

  49-55

Abstract

 Aim: The aim of the study was to assess the effectiveness of VITAMIN D3 [1, 25(OH)2D3] treatment in IBD with regard to tumor necrosis factor-alpha (TNF-a) serum level and clinical disease activity index (CDAI).Background: VITAMIN D has immune-regulatory functions in experimental INFLAMMATORY BOWEL DISEASE (IBD) and VITAMIN D deficiency is common in IBD patients.Patients and methods: This was a randomized clinical trial on 108 IBD patients with serum 25-OHD levels less than 30ng/ml, which divided into VITAMIN D and control groups. VITAMIN D group received 50000 IU VITAMIN D3 for 12 weeks. Before and after the study, TNF-a and 25-OHD serum levels were measured by ELISA method. Data were analyzed using paired t-test, chi-square test and Spearman correlation coefficient. P-values less than 0.05 were considered statistically significant.Results: Before the intervention no significant difference was found between baseline characteristics and TNF-a serum level of two groups. After intervention TNF-a serum level reduced but this reduction was not statistically significant (p=0.07, 95% CI: -0.45 to 8.14). The mean serum 25-OHD level of VITAMIN D increased from 15.54 to 67.89, which was statistically significant (p= 0.00, 95% CI: -61.40 to -43.30). TNF-a level was also associated significantly with CDAI before (Spearman’s rho: 0.3, p<0.0001) and after (Spearman’s rho: 0.27, P=0.01) intervention.Conclusion: Oral supplementation VITAMIN D3 significantly increased serum VITAMIN D levels and insignificantly reduced serum TNF-a level. More studies with larger samples would be beneficial to assess VITAMIN D3 supplementation efficient effect in IBD.

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    APA: Copy

    DADAEI, TAHEREH, SAFAPOOR, MOHAMMAD HOSEIN, ASADZADEH AGHDAEI, HAMID, BALAII, HEDIE, POURHOSEINGHOLI, MOHAMMAD AMIN, NADERI, NOSRATOLLAH, ZOJAJI, HOMAYOON, AZIMZADEH, PEDRAM, MOHAMMADI, PARVANEH, & ZALI, MOHAMMAD REZA. (2015). EFFECT OF VITAMIN D3 SUPPLEMENTATION ON TNF-α SERUM LEVEL AND DISEASE ACTIVITY INDEX IN IRANIAN IBD PATIENTS. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(1), 49-55. SID. https://sid.ir/paper/324595/en

    Vancouver: Copy

    DADAEI TAHEREH, SAFAPOOR MOHAMMAD HOSEIN, ASADZADEH AGHDAEI HAMID, BALAII HEDIE, POURHOSEINGHOLI MOHAMMAD AMIN, NADERI NOSRATOLLAH, ZOJAJI HOMAYOON, AZIMZADEH PEDRAM, MOHAMMADI PARVANEH, ZALI MOHAMMAD REZA. EFFECT OF VITAMIN D3 SUPPLEMENTATION ON TNF-α SERUM LEVEL AND DISEASE ACTIVITY INDEX IN IRANIAN IBD PATIENTS. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(1):49-55. Available from: https://sid.ir/paper/324595/en

    IEEE: Copy

    TAHEREH DADAEI, MOHAMMAD HOSEIN SAFAPOOR, HAMID ASADZADEH AGHDAEI, HEDIE BALAII, MOHAMMAD AMIN POURHOSEINGHOLI, NOSRATOLLAH NADERI, HOMAYOON ZOJAJI, PEDRAM AZIMZADEH, PARVANEH MOHAMMADI, and MOHAMMAD REZA ZALI, “EFFECT OF VITAMIN D3 SUPPLEMENTATION ON TNF-α SERUM LEVEL AND DISEASE ACTIVITY INDEX IN IRANIAN IBD PATIENTS,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 1, pp. 49–55, 2015, [Online]. Available: https://sid.ir/paper/324595/en

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