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Information Journal Paper

Title

SYNBIOTIC CONTAINING BACILLUS COAGULANS AND FRUCTO-OLIGOSACCHARIDES FOR FUNCTIONAL ABDOMINAL PAIN IN CHILDREN

Pages

  56-65

Abstract

 Aim: We evaluated the effectiveness of a SYNBIOTIC in the treatment of CHILDhood functional ABDOMINAL PAIN (FAP).Background: PROBIOTICs are effective in the treatment of functional gastrointestinal disorders in adult patients, but there is lack of information in CHILDren.Patients and methods: CHILDren with FAP, based on the Rome III criteria (n=115, aged 6-18 years), were randomized to receive either SYNBIOTIC (Bacillus coagulans, Unique IS-2, 150 million spore plus FOS, 100 mg) twice daily or placebo for four weeks. Treatment response was defined as³2-point reduction in the 6-point self-rated pain scale or “no pain”. Physician-rated global severity and improvement were also evaluated. Patients were followed for a total of 12 weeks.Results: Eighty-eight patients completed the trial (45 with SYNBIOTIC). Response rate was higher with SYNBIOTIC than placebo after medication (60% vs. 39.5%, P=0.044), but was not different between the two groups at week 12 (64.4% vs. 53.4%, P=0.204). Difference between the two groups regarding the physician-rated global severity over the study period was not statistically significant (z=-1.87, P=0.062). There was no significant difference between the two groups in physician-rated global improvement (week 4, P=0.437; week 12, P=0.111). Receiving SYNBIOTIC (OR 2.608, 95% CI: 1.01-6.68) and baseline pain score (OR 2.21, 95% CI: 1.19-4.10) were predictors of treatment response after medication.Conclusion: The SYNBIOTIC containing Bacillus coagulans and FOS seems to be effective in the treatment of CHILDhood FAP. Further trials are recommended in this regard.

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    APA: Copy

    SANEIAN, HOSSEIN, POURMOGHADDAS, ZAHRA, ROOHAFZA, HAMIDREZA, & GHOLAMREZAEI, ALI. (2015). SYNBIOTIC CONTAINING BACILLUS COAGULANS AND FRUCTO-OLIGOSACCHARIDES FOR FUNCTIONAL ABDOMINAL PAIN IN CHILDREN. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(1), 56-65. SID. https://sid.ir/paper/324606/en

    Vancouver: Copy

    SANEIAN HOSSEIN, POURMOGHADDAS ZAHRA, ROOHAFZA HAMIDREZA, GHOLAMREZAEI ALI. SYNBIOTIC CONTAINING BACILLUS COAGULANS AND FRUCTO-OLIGOSACCHARIDES FOR FUNCTIONAL ABDOMINAL PAIN IN CHILDREN. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(1):56-65. Available from: https://sid.ir/paper/324606/en

    IEEE: Copy

    HOSSEIN SANEIAN, ZAHRA POURMOGHADDAS, HAMIDREZA ROOHAFZA, and ALI GHOLAMREZAEI, “SYNBIOTIC CONTAINING BACILLUS COAGULANS AND FRUCTO-OLIGOSACCHARIDES FOR FUNCTIONAL ABDOMINAL PAIN IN CHILDREN,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 1, pp. 56–65, 2015, [Online]. Available: https://sid.ir/paper/324606/en

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