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Information Journal Paper

Title

DOES GLUTEN FREE DIET HAVE MORE IMPLICATIONS THAN TREATMENT OF CELIAC DISEASE?

Pages

  160-166

Abstract

 Aim: This study was aimed to evaluate symptomatic as well as histopathologic response to GFD in patients with gluten-sensitive enteropathies including CELIAC DISEASE, lymphocytic duodenosis and non-specific duodenitis.Background: Gluten-free diet (GFD) is the main treatment of CELIAC DISEASE. However, its impact on other disorders of GLUTEN SENSITIVITY spectrum is less clear.Patients and methods: In a prospective observational study in Modarres hospital Tehran, Iran, 35 patients with chronic manifestations including low BMI, diarrhea, greasy stool and bloating were evaluated using serology for anti-tTG, endoscopy and histopathology. Patients were categorized in three diagnostic groups accordingly including CELIAC DISEASE (CD), lymphocytic doudenosis (LD) and non-specific duodenitis (NSD). All patients were put on a GFD for 6 months, and subjective symptomatic response, serology, endoscopy and histopathologic tests were repeated and compared with baselines and among groups.Results: Of the total 35 patients, 5 had CD (14.3%), 9 had LD (25.7%) and 21 (60%) had NSD. Bloating was the most common symptom followed by diarrhea. Majority of patients (80%) had low BMI. All symptoms alleviated following a GFD but bloating was the only significant one. A significant increase was found in total mean BMI (17.3±0.7 v.s. 17.9±0.9). Histopathologic examination showed a complete resolution in 48.5% (n=17) patients, 10 in NSD group, 4 in LD group and 3 in CD group. Final prevalence of gluten-sensitive enteropathy (LD and NSD cases that responded to GFD) was 46.6%.Conclusion: GFD may have more implications other than CELIAC DISEASE. Other gluten-sensitive enteropathies, like LD and NSD, might also respond to this treatment particularly in patients with low BMI.

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    APA: Copy

    TALAIE, RAMIN. (2015). DOES GLUTEN FREE DIET HAVE MORE IMPLICATIONS THAN TREATMENT OF CELIAC DISEASE?. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(2), 160-166. SID. https://sid.ir/paper/324610/en

    Vancouver: Copy

    TALAIE RAMIN. DOES GLUTEN FREE DIET HAVE MORE IMPLICATIONS THAN TREATMENT OF CELIAC DISEASE?. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(2):160-166. Available from: https://sid.ir/paper/324610/en

    IEEE: Copy

    RAMIN TALAIE, “DOES GLUTEN FREE DIET HAVE MORE IMPLICATIONS THAN TREATMENT OF CELIAC DISEASE?,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 2, pp. 160–166, 2015, [Online]. Available: https://sid.ir/paper/324610/en

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