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Information Journal Paper

Title

SEROLOGIC EVALUATION OF CELIAC DISEASE IN PATIENTS WITH BETA THALASSEMIA MAJOR AND CONTROL

Pages

  153-159

Abstract

 Aim: This study reports evaluated prevalence of CD in patients with BETA-THALASSEMIA MAJOR.Background: CELIAC DISEASE (CD) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals.Patients and methods: In this case-control study in a period of 3 years, which was performed on 620 children in two groups of BETA-THALASSEMIA MAJOR patients (n=200) and control (n=420), serum tissue transglutamianse (tTG) IgA levels were measured. The two groups were compared together in terms of tTG IgA levels, and p<0.05 was considered significant.Results: The means of serum tTG IgA levels in patients with BETA-THALASSEMIA MAJOR and control groups were 28.81±68.44 and 6.94±6.68 U/mL, respectively. There was a significant difference in favor of the case group (p=0.000). Body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001). Belonging to each group will change the probability of having less than 20 in tTG IgA (odds=0.285) and it means that belonging to the control group has a protective role. There is only a significant association in the case of all population (r=0.102, p=0.011). Body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001).Conclusion: Probability of CD should be considered since the prevalence of CD is high in patients with and BETA-THALASSEMIA MAJOR. Patients with thalassemia major are recommended for screening for CD.

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    APA: Copy

    SHAHRAMIAN, IRAJ, DEHGHANI, SEYED MOHSEN, HAGHIGHAT, MAHMOOD, NOORI, NOOR MOHAMMAD, TEIMOURI, ALI REZA, SHARAFI, ELHAM, & KHALILI, MANIJEH. (2015). SEROLOGIC EVALUATION OF CELIAC DISEASE IN PATIENTS WITH BETA THALASSEMIA MAJOR AND CONTROL. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(2), 153-159. SID. https://sid.ir/paper/324616/en

    Vancouver: Copy

    SHAHRAMIAN IRAJ, DEHGHANI SEYED MOHSEN, HAGHIGHAT MAHMOOD, NOORI NOOR MOHAMMAD, TEIMOURI ALI REZA, SHARAFI ELHAM, KHALILI MANIJEH. SEROLOGIC EVALUATION OF CELIAC DISEASE IN PATIENTS WITH BETA THALASSEMIA MAJOR AND CONTROL. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(2):153-159. Available from: https://sid.ir/paper/324616/en

    IEEE: Copy

    IRAJ SHAHRAMIAN, SEYED MOHSEN DEHGHANI, MAHMOOD HAGHIGHAT, NOOR MOHAMMAD NOORI, ALI REZA TEIMOURI, ELHAM SHARAFI, and MANIJEH KHALILI, “SEROLOGIC EVALUATION OF CELIAC DISEASE IN PATIENTS WITH BETA THALASSEMIA MAJOR AND CONTROL,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 2, pp. 153–159, 2015, [Online]. Available: https://sid.ir/paper/324616/en

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