مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SYNTHESIS AND EVALUATION OF MULTI-WALL CARBON NANOTUBE–PACLITAXEL COMPLEX AS AN ANTI-CANCER AGENT

Pages

  197-204

Abstract

 Aim: The aim of this study was to design MULTI-WALLED CARBON NANOTUBES (MWCNTs) loaded with PACLITAXEL (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human GASTRIC CANCER.Background: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading.Patients and methods: In this study, MULTI-WALLED CARBON NANOTUBES (MWCNTs) pre-functionalized covalently with a PACLITAXEL (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses.Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line.Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport.

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  • Cite

    APA: Copy

    GHASEMVAND, FARIBA, BIAZAR, ESMAEIL, TAVAKOLIFARD, SARA, KHALEDIAN, MOHAMMAD, RAHMANZADEH, SAEID, MOMENZADEH, DARUOSH, AFROOSHEH, ROSHANAK, ZARKALAMI, FAEZEH, SHABANNEZHAD, MARJAN, HESAMI TACKALLOU, SAEED, MASSOUDI, NILOFAR, & HEIDARI KESHEL, SAEED. (2016). SYNTHESIS AND EVALUATION OF MULTI-WALL CARBON NANOTUBE–PACLITAXEL COMPLEX AS AN ANTI-CANCER AGENT. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 9(3), 197-204. SID. https://sid.ir/paper/324665/en

    Vancouver: Copy

    GHASEMVAND FARIBA, BIAZAR ESMAEIL, TAVAKOLIFARD SARA, KHALEDIAN MOHAMMAD, RAHMANZADEH SAEID, MOMENZADEH DARUOSH, AFROOSHEH ROSHANAK, ZARKALAMI FAEZEH, SHABANNEZHAD MARJAN, HESAMI TACKALLOU SAEED, MASSOUDI NILOFAR, HEIDARI KESHEL SAEED. SYNTHESIS AND EVALUATION OF MULTI-WALL CARBON NANOTUBE–PACLITAXEL COMPLEX AS AN ANTI-CANCER AGENT. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2016;9(3):197-204. Available from: https://sid.ir/paper/324665/en

    IEEE: Copy

    FARIBA GHASEMVAND, ESMAEIL BIAZAR, SARA TAVAKOLIFARD, MOHAMMAD KHALEDIAN, SAEID RAHMANZADEH, DARUOSH MOMENZADEH, ROSHANAK AFROOSHEH, FAEZEH ZARKALAMI, MARJAN SHABANNEZHAD, SAEED HESAMI TACKALLOU, NILOFAR MASSOUDI, and SAEED HEIDARI KESHEL, “SYNTHESIS AND EVALUATION OF MULTI-WALL CARBON NANOTUBE–PACLITAXEL COMPLEX AS AN ANTI-CANCER AGENT,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 9, no. 3, pp. 197–204, 2016, [Online]. Available: https://sid.ir/paper/324665/en

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