مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

ORAL SQUAMOUS CELL CANCER PROTEIN-PROTEIN INTERACTION NETWORK INTERPRETATION IN COMPARISON TO ESOPHAGEAL ADENOCARCINOMA

Pages

  118-124

Keywords

ORAL SQUAMOUS CELL CANCER (OSCC) 

Abstract

 Aim: The aim of this study is to present the oral Squamous Cell Cancer protein-protein interaction network interpretation in comparison to esophageal adenocarcinoma.Background: Oral squamous cell cancer (OSCC) is a common disease worldwide, with poor prognosis and limited treatment. Thus, introducing molecular markers through network analysis can be helpful.Methods: STRING database (DB) was applied for network construction through Cytoscape 3.4.0. Clue GO handled the gene annotation for the retrieved clusters. Eight proteins were indicated to be differential in the network constitution.Results: The centrality and CLUSTERING ANALYSIS indicate that TP53 plays an over-significant role in network integrity among eight most central proteins including TP53, AKT1, EGFR, MYC, JUN, CDH1, CCND1, and CTNNB1. The suggested biomarker set is very similar to the related biomarker panel of esophageal adenocarcinoma.Conclusion: The ontology analysis implies that the prominent proteins are involved in regulation of smooth muscle cell proliferation, regulation of fibroblast proliferation, and response to UV-A processes. In conclusion, these proteins and their associated biological processes may be more critical compared to other reported biomarkers for OSCC. Nevertheless, validation studies are required for confirming the pivotal role of potential candidates. Similar biomarker panel of this disease and esophagus adenocarcinoma is corresponded to the origin of the two malignancies.

Cites

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  • Cite

    APA: Copy

    KHAYER, NASIBEH, ZAMANIAN AZODI, MONA, MANSOURI, VAHID, GHASSEMI BOROUMAND, MOHAMMAD, REZAEI TAVIRANI, MOSTAFA, HEYDARI, MOHAMMAD HOSSEIN, & REZAEI TAVIRANI, MAJID. (2017). ORAL SQUAMOUS CELL CANCER PROTEIN-PROTEIN INTERACTION NETWORK INTERPRETATION IN COMPARISON TO ESOPHAGEAL ADENOCARCINOMA. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(2), 118-124. SID. https://sid.ir/paper/324687/en

    Vancouver: Copy

    KHAYER NASIBEH, ZAMANIAN AZODI MONA, MANSOURI VAHID, GHASSEMI BOROUMAND MOHAMMAD, REZAEI TAVIRANI MOSTAFA, HEYDARI MOHAMMAD HOSSEIN, REZAEI TAVIRANI MAJID. ORAL SQUAMOUS CELL CANCER PROTEIN-PROTEIN INTERACTION NETWORK INTERPRETATION IN COMPARISON TO ESOPHAGEAL ADENOCARCINOMA. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(2):118-124. Available from: https://sid.ir/paper/324687/en

    IEEE: Copy

    NASIBEH KHAYER, MONA ZAMANIAN AZODI, VAHID MANSOURI, MOHAMMAD GHASSEMI BOROUMAND, MOSTAFA REZAEI TAVIRANI, MOHAMMAD HOSSEIN HEYDARI, and MAJID REZAEI TAVIRANI, “ORAL SQUAMOUS CELL CANCER PROTEIN-PROTEIN INTERACTION NETWORK INTERPRETATION IN COMPARISON TO ESOPHAGEAL ADENOCARCINOMA,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. 2, pp. 118–124, 2017, [Online]. Available: https://sid.ir/paper/324687/en

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