A gene variation of Interferon Gamma Receptor-I promoter (rs1327474A>G) and chronic hepatitis C virus infection

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KARKHANE MARYAM; MOHEBBI SEYED REZA; SHARIFIAN AFSANEH; GHAEMI AMIR; ASADZADEH AGHDAEI HAMID; ZALI MOHAMMAD REZA

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2019 | Volume:12 | Issue:1 Page(s): 46-51

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Title

A gene variation of Interferon Gamma Receptor-I promoter (rs1327474A>G) and chronic hepatitis C virus infection

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Keywords

Single nucleotide polymorphism

Chronic disease

HCV infection

IFNGR1

Abstract

Aim: In present survey, we attempted to inquire the plausible linkage of rs1327474 A/G and HCV chronic infection or the clearance of the virus. Background: IFN-γ signaling pathway is an important trigger for activating antiviral immune responses and production of wide variety of molecules with anti-microbial profiles including type 1 cytokines. Any defect or variation in IFNG signaling pathway may result in susceptibility or progression to diverse diseases such as inflammatory and virus associated disorders. Rs1327474 A/G also known as-611 A/G is an important variation which is located in promoter region of Interferon Gamma Receptor-I (IFNGR1) and may have potent risk for HCV susceptibility. Methods: For this purpose, 154 HCV patients and 200 controls were enrolled in the study, and genomic DNA was isolated from PBMCS and IFNGR1-611 polymorphism was genotyped by polymerase chain reaction-fragments length polymorphism (PCRRFLP) method. Results: While, AA, AG and GG genotypes frequency included 37. 8%, 53. 7%, 8. 5% in healthy controls, 41. 6%, 46. 1%, 12. 3% were found in chronic HCV patients. Interestingly, allelic percentage was similar in both separated groups within 64. 7%, 35. 3% and 65. 3%, 34. 7% were obtained for T and G allele in control and case group respectively. Conclusion: In spite of our exception for the possible role of this variation in an important promoter region of IFGR1 gene, rs1327474 A/G was not associated with HCV chronic infection among an Iranian studied group. Comprehensively,-611A/G cannot be considered as a risk biomarker for susceptibility to chronic HCV disease.

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APA: Copy

KARKHANE, MARYAM, MOHEBBI, SEYED REZA, SHARIFIAN, AFSANEH, GHAEMI, AMIR, ASADZADEH AGHDAEI, HAMID, & ZALI, MOHAMMAD REZA. (2019). A gene variation of Interferon Gamma Receptor-I promoter (rs1327474A>G) and chronic hepatitis C virus infection. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 12(1), 46-51. SID. https://sid.ir/paper/324748/en

Vancouver: Copy

KARKHANE MARYAM, MOHEBBI SEYED REZA, SHARIFIAN AFSANEH, GHAEMI AMIR, ASADZADEH AGHDAEI HAMID, ZALI MOHAMMAD REZA. A gene variation of Interferon Gamma Receptor-I promoter (rs1327474A>G) and chronic hepatitis C virus infection. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2019;12(1):46-51. Available from: https://sid.ir/paper/324748/en

IEEE: Copy

MARYAM KARKHANE, SEYED REZA MOHEBBI, AFSANEH SHARIFIAN, AMIR GHAEMI, HAMID ASADZADEH AGHDAEI, and MOHAMMAD REZA ZALI, “A gene variation of Interferon Gamma Receptor-I promoter (rs1327474A>G) and chronic hepatitis C virus infection,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. 1, pp. 46–51, 2019, [Online]. Available: https://sid.ir/paper/324748/en

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