مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer

Pages

  48-53

Abstract

 Aim: In present study we have elucidated the role of 2758 A>G (rs696), in the recognition site of miR449a in the 3′ UTR of NFKB inhibitor alpha (NFKBIA) gene, in development of sporadic colorectal Cancer. Background: colorectal Cancer (CRC) is rated as second cause of cancer death. Genetic determinants are considered as driving forces in development of sporadic CRC. Single nucleotide polymorphisms (SNPs), are attributed as the main genetic factor in cancers susceptibility. microRNAs, are key players in post-translational gene regulation by binding to their specific recognition sequences located at 3' untranslated region (UTR) of mRNAs. Methods: A case– control study using 143 CRC patients and 137 noncancerous counterparts were undertaken in order to determine rs696 genotypes using polymerase chain reaction– restriction fragment length polymorphism (PCR– RFLP) method. Results: There was a significant difference for the genotype frequencies of rs696 between patients and controls. The frequencies of GG, AG, AA genotypes in the control group were 38. 7, 45. 3, and 16. 1 %, respectively, and the genotype frequencies in case group were 19. 6, 40. 6, and 39. 9 %, respectively. Conclusion: Our results suggest significant correlation between rs696 polymorphism and colorectal Cancer risk.

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    APA: Copy

    SIMONIAN, MIGANOOSH, MOSALLAYI, MEYSAM, MIRAGHAJANI, MARYAM, FEIZI, AWAT, KHOSRAVI, SHARIFEH, Salehi, ahmad reza, Mortazavi, Deniz, & SABERI, FARIDEH. (2018). Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(1), 48-53. SID. https://sid.ir/paper/324755/en

    Vancouver: Copy

    SIMONIAN MIGANOOSH, MOSALLAYI MEYSAM, MIRAGHAJANI MARYAM, FEIZI AWAT, KHOSRAVI SHARIFEH, Salehi ahmad reza, Mortazavi Deniz, SABERI FARIDEH. Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(1):48-53. Available from: https://sid.ir/paper/324755/en

    IEEE: Copy

    MIGANOOSH SIMONIAN, MEYSAM MOSALLAYI, MARYAM MIRAGHAJANI, AWAT FEIZI, SHARIFEH KHOSRAVI, ahmad reza Salehi, Deniz Mortazavi, and FARIDEH SABERI, “Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. 1, pp. 48–53, 2018, [Online]. Available: https://sid.ir/paper/324755/en

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