Comparison of Helicobacter pylori eradication regimens in patients with end stage renal disease

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SEYYEDMAJIDI MOHAMMADREZA; Sanjari Pirayvatlou Peyman; Rajabikashani Majid; Firoozabadi Mona; Seyed Majidi Seyed ali; VAFAEIMANESH JAMSHID

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2018 | Volume:11 | Issue:1 Page(s): 15-19

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Title

Comparison of Helicobacter pylori eradication regimens in patients with end stage renal disease

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Keywords

End Stage Renal Disease

Eradication therapy

Helicobacter pylori

Abstract

Aim: The aim of this study was to compare the Helicobacter pylori (HP) eradication regimens in patients with End Stage Renal Disease. Background: In patients undergoing hemodialysis, the pathologic changes seen in the stomach may be the result of high serum levels of gastrin, delayed gastric emptying or HP infection. Methods: Our study was a randomized clinical trial in which 120 patients with ESRD (Patients who undergo hemodialysis) confirmed HP infection, were divided to four groups having 2-week eradication regimens; Group I: LCA (lansoprazole 30 mg-BD, clarithromycin 250 mg-BD, amoxicillin 500 mg-BD), Group II: LCM (lansoprazole 30 mg-BD, clarithromycin 250 mg-BD, metronidazole 500 mg-BD), Group III: LCAM (lansoprazole 30 mg-BD, clarithromycin 250 mg-BD, amoxicillin 500 mg-BD, metronidazole 500 mg-BD) and Group IV: Sequential (lansoprazole 30 mg-BDfor two weeks; first week: amoxicillin 500 mg-BD and second week: clarithromycin 250 mg-BD, metronidazole 500 mg-BD). 6 weeks after treatment, Urea Breath Test (UBT) was performed for all patients. Results: The mean age of patients was 43. 1± 11. 2 years. 55. 8% of patients were male. The success rates of HP eradication in 4 groups were76. 7%, 70%, 90% and 90%, respectively. HP eradication rates were not statistically different among the regimens (p=0. 11). There were not significant differences among the groups regarding demographic and anthropometric variables. Conclusion: The results showed there was no significant difference between the success rates of HP eradication regimens for ESRD patients. According to approved regimen for 90% eradication rate, with a lower number of medications and given the less risk of side effects and drug interactions, the sequential regimen is the best.

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APA: Copy

SEYYEDMAJIDI, MOHAMMADREZA, Sanjari Pirayvatlou, Peyman, Rajabikashani, Majid, Firoozabadi, Mona, Seyed Majidi, Seyed ali, & VAFAEIMANESH, JAMSHID. (2018). Comparison of Helicobacter pylori eradication regimens in patients with end stage renal disease. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(1), 15-19. SID. https://sid.ir/paper/324758/en

Vancouver: Copy

SEYYEDMAJIDI MOHAMMADREZA, Sanjari Pirayvatlou Peyman, Rajabikashani Majid, Firoozabadi Mona, Seyed Majidi Seyed ali, VAFAEIMANESH JAMSHID. Comparison of Helicobacter pylori eradication regimens in patients with end stage renal disease. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(1):15-19. Available from: https://sid.ir/paper/324758/en

IEEE: Copy

MOHAMMADREZA SEYYEDMAJIDI, Peyman Sanjari Pirayvatlou, Majid Rajabikashani, Mona Firoozabadi, Seyed ali Seyed Majidi, and JAMSHID VAFAEIMANESH, “Comparison of Helicobacter pylori eradication regimens in patients with end stage renal disease,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. 1, pp. 15–19, 2018, [Online]. Available: https://sid.ir/paper/324758/en

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