Levofloxacin based vs clarithromycin based sequential therapy in helicobacter pylori eradication; a randomized clinical trial

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MORADNIANI MOSAYEB; MIRBEIK SABZEVARI ZOHRE; Jaferian Soleiman; SHAFIEZADEH SHIVA; EHSANI ARDAKANI MOHAMMAD JAVAD; Mirzaee Roozbahany Mehrdad; AZADBAKHT SALEH; Sherkatolabbasieh Hamidreza

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2018 | Volume:11 | Issue:1 Page(s): 20-26

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Title

Levofloxacin based vs clarithromycin based sequential therapy in helicobacter pylori eradication; a randomized clinical trial

Author(s)

Keywords

sequential therapy

Levofluxacin

Clarithromycin

Helicobacter pylori eradication

Abstract

Aim: This study was aimed to evaluating the efficacy of levofloxacin based sequential therapy vs Clarithromycin based sequential therapy in h. pylori (HP) eradication. Background: Several therapeutic regimen were investigated to treat HP infection. sequential therapy is an alternative to classic triple therapy. Methods: In this randomized clinical trial, 200 HP infected patients randomly divided into two therapeutic groups. 1-Levofloxacin based sequential regimen (group A); omeprazole and amoxicillin for 7days followed by omeprazole, amoxicillin and levofloxacin for 7days. 2-Clarithromycin based sequential regimen (group B): omeprazole and amoxicillin for 7days followed by omeprazole, amoxicillin and Clarithromycin for 7days. HP eradication was evaluated with urea breath test with carbon 13 (UBT) 6 weeks after the end of treatment. Results: Per protocol eradication rates of group A and B were 87. 6% and 76% respectively. By intention to treat analysis, eradication rate of group A and B groups were 85. 1% and 73% respectively. Levofloxacin based sequential regimen was more effective than Clarithromycin based sequential regimen (Pv=0. 028). Adverse events were seen in 19. 6% and 15. 6% in group A and B respectively. Drug compliance was 97% in group A and 96% in group B. There was no significant difference between two groups in term of adverse events (p=0. 470) and compliance (p=0. 651). Conclusion: Levofluxacin based sequential therapy was more effective than Clarithromycin based sequential therapy in HP eradication. The suggested Levofluxacin based sequential therapy could be an alternative therapy in area with high Clarithromycin resistance. Further studies are needed to confirm these findings.

Cites

Levofloxacin-Based Regimen Versus Bismuth Quadruple Regimen for Helicobacter pylori Eradication in Kurdistan Region, Iraq

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APA: Copy

MORADNIANI, MOSAYEB, MIRBEIK SABZEVARI, ZOHRE, Jaferian, Soleiman, SHAFIEZADEH, SHIVA, EHSANI ARDAKANI, MOHAMMAD JAVAD, Mirzaee Roozbahany, Mehrdad, AZADBAKHT, SALEH, & Sherkatolabbasieh, Hamidreza. (2018). Levofloxacin based vs clarithromycin based sequential therapy in helicobacter pylori eradication; a randomized clinical trial. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(1), 20-26. SID. https://sid.ir/paper/324759/en

Vancouver: Copy

MORADNIANI MOSAYEB, MIRBEIK SABZEVARI ZOHRE, Jaferian Soleiman, SHAFIEZADEH SHIVA, EHSANI ARDAKANI MOHAMMAD JAVAD, Mirzaee Roozbahany Mehrdad, AZADBAKHT SALEH, Sherkatolabbasieh Hamidreza. Levofloxacin based vs clarithromycin based sequential therapy in helicobacter pylori eradication; a randomized clinical trial. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(1):20-26. Available from: https://sid.ir/paper/324759/en

IEEE: Copy

MOSAYEB MORADNIANI, ZOHRE MIRBEIK SABZEVARI, Soleiman Jaferian, SHIVA SHAFIEZADEH, MOHAMMAD JAVAD EHSANI ARDAKANI, Mehrdad Mirzaee Roozbahany, SALEH AZADBAKHT, and Hamidreza Sherkatolabbasieh, “Levofloxacin based vs clarithromycin based sequential therapy in helicobacter pylori eradication; a randomized clinical trial,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. 1, pp. 20–26, 2018, [Online]. Available: https://sid.ir/paper/324759/en

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