مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

193
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

122
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Network analysis of grade II into grade III transition in rectum cancer patients

Pages

  118-123

Keywords

Abstract

 Aim: Finding important differential Genes between grade II and grade III of Rectum Cancer was the aim of this study. Background: Colorectal (CRC) Cancers (CRC) are known as the third diagnosed Cancer and the second leading to death Cancers. Life style is an important risk factor of CRCs. Diagnosis of Rectum Cancer estimated as 44% of colon Cancer. Methods: Differentially expressed Genes (DEGS) related to grade II into grade II in 6 patients are retrieved from Gene expression omnibus (GEO) and investigated by Protein-Protein interaction (PPI) network analysis. Central nodes of the network are identified and enriched to determine biochemical pathways. Action map is illustrated for the central Genes. Results: Among 15 central Genes including AKT1, PRDM10, GAPDH, TP53, SRC, EGFR, ALB, INS, CTNNB1, EGF, IL6, RHOA, DECR1, ACACA, GMPS role of AKT1 is highlighted due to prominent role in the integrity of the network and participation in the most determined pathways. However, significant regulatory effect of INS, AKT1, EGF, EGFR, and CTNNB1 is tinted in action map. Conclusion: It seems that AKT1, EGFR, and TP3 are suitable drug targets to prevent Rectum Cancer progression.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    ROSTAMI NEJAD, MOHAMMAD, MANSOURI, VAHID, MAHMOUD ROBATI, REZA, MOHAGHEGH SHALMANI, HAMID, MAHMOUDI LAMOUKI, REZA, & REZAEI TAVIRANI, MOSTAFA. (2018). Network analysis of grade II into grade III transition in rectum cancer patients. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(suppl 1), 118-123. SID. https://sid.ir/paper/324807/en

    Vancouver: Copy

    ROSTAMI NEJAD MOHAMMAD, MANSOURI VAHID, MAHMOUD ROBATI REZA, MOHAGHEGH SHALMANI HAMID, MAHMOUDI LAMOUKI REZA, REZAEI TAVIRANI MOSTAFA. Network analysis of grade II into grade III transition in rectum cancer patients. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(suppl 1):118-123. Available from: https://sid.ir/paper/324807/en

    IEEE: Copy

    MOHAMMAD ROSTAMI NEJAD, VAHID MANSOURI, REZA MAHMOUD ROBATI, HAMID MOHAGHEGH SHALMANI, REZA MAHMOUDI LAMOUKI, and MOSTAFA REZAEI TAVIRANI, “Network analysis of grade II into grade III transition in rectum cancer patients,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. suppl 1, pp. 118–123, 2018, [Online]. Available: https://sid.ir/paper/324807/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button