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Information Journal Paper

Title

Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease

Pages

  8-13

Abstract

 Aim: The aim of this study was to examine the effects of Curcumin supplementation on Hepatic Fibrosis using different fibrosis assessment methods. Background: Nonalcoholic fatty liver disease (NAFLD) may progress to Hepatic Fibrosis. Detection of Hepatic Fibrosis should be measured by liver biopsy, which is an invasive method. Thus, some non-invasive methods are suggested. Methods: Hepatic Fibrosis was evaluated in forty six patients with NAFLD before and three months after supplementation with 1. 5 gram Curcumin or placebo. Methods of assessments included fibroscan, and calculating non-invasive marker panel including FIB-4 (Fibrosis4), NFS (NAFLD fibrosis score), APRI (AST (Aspartate aminotransferase) Platelet Ratio Index), and BARD (body mass index, AST/ALT (Alanine aminotransferase ratio, diabetes). Results: Fibrosis score was reduced significantly after Curcumin supplementation using fibroscan (p<0. 01), FIB-4 (p<0. 05) and APRI (p<0. 05) tests, while fibrosis score did not change significantly using BARD and NFS methods (p>0. 05). Conclusion: Our results revealed that fibroscan, FIB-4, and APRI are similar in assessment of Hepatic Fibrosis changes after Curcumin supplementation. Future studies with higher sample sizes are needed to confirm these results.

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    APA: Copy

    Saadati, Saeede, HEKMATDOOST, AZITA, HATAMI, BEHZAD, Mansour, Asieh, YARI, ZAHRA, HEDAYATI, MEHDI, & SADEGHI, AMIR. (2018). Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(suppl 1), 8-13. SID. https://sid.ir/paper/324815/en

    Vancouver: Copy

    Saadati Saeede, HEKMATDOOST AZITA, HATAMI BEHZAD, Mansour Asieh, YARI ZAHRA, HEDAYATI MEHDI, SADEGHI AMIR. Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(suppl 1):8-13. Available from: https://sid.ir/paper/324815/en

    IEEE: Copy

    Saeede Saadati, AZITA HEKMATDOOST, BEHZAD HATAMI, Asieh Mansour, ZAHRA YARI, MEHDI HEDAYATI, and AMIR SADEGHI, “Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. suppl 1, pp. 8–13, 2018, [Online]. Available: https://sid.ir/paper/324815/en

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