مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

Tumor suppressor genes in familial adenomatous polyposis

Pages

  3-13

Keywords

familial adenomatous polyposis (FAP) 
tumor suppressor genes (TSGs) 
adenomatous polyposis coli (APC) 

Abstract

 Colorectal cancer (CRC) is mostly due to a series of genetic alterations that are being greatly under the influence of the environmental factors. These changes, mutational or epigenetic modifications at transcriptional forefront and/or post-transcriptional effects via miRNAs, include inactivation and the conversion of proto-oncogene to oncogenes, and/or inactivation of tumor suppressor genes (TSG). Here, a thorough review was carried out on the role of TSGs with the focus on the APC as the master regulator, mutated genes and mal-/dysfunctional pathways that lead to one type of hereditary form of the CRC; namely familial adenomatous polyposis (FAP). This review provides a venue towards defining candidate genes that can be used as new PCR-based markers for early diagnosis of FAP. In addition to diagnosis, defining the modes of genetic alterations will open door towards genome editing to either suppress the disease or reduce its progression during the course of action.

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  • Cite

    APA: Copy

    Eshghifar, Nahal, FARROKHI, NASER, NAJI, TAHEREH, & ZALI, MOHAMMADREZA. (2017). Tumor suppressor genes in familial adenomatous polyposis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(1), 3-13. SID. https://sid.ir/paper/324828/en

    Vancouver: Copy

    Eshghifar Nahal, FARROKHI NASER, NAJI TAHEREH, ZALI MOHAMMADREZA. Tumor suppressor genes in familial adenomatous polyposis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(1):3-13. Available from: https://sid.ir/paper/324828/en

    IEEE: Copy

    Nahal Eshghifar, NASER FARROKHI, TAHEREH NAJI, and MOHAMMADREZA ZALI, “Tumor suppressor genes in familial adenomatous polyposis,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. 1, pp. 3–13, 2017, [Online]. Available: https://sid.ir/paper/324828/en

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