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Cites:

1

Information Journal Paper

Title

Protein-protein interaction network of celiac disease ()

Pages

  268-277

Abstract

 Aim: The aim of this study is to investigate the Protein-protein interaction Network of celiac disease. Background: celiac disease (CD) is an autoimmune disease with susceptibility of individuals to gluten of wheat, rye and barley. Understanding the molecular mechanisms and involved pathway may lead to the development of drug target discovery. The protein interaction Network is one of the supportive fields to discover the pathogenesis biomarkers for celiac disease. Material and methods: In the present study, we collected the articles that focused on the proteomic data in celiac disease. According to the gene expression investigations of these articles, 31 candidate proteins were selected for this study. The Networks of related differentially expressed protein were explored using Cytoscape 3. 3 and the PPI analysis methods such as MCODE and ClueGO. Results: According to the Network analysis Ubiquitin C, Heat shock protein 90kDa alpha (cytosolic and Grp94); class A, B and 1 member, Heat shock 70kDa protein, and protein 5 (glucose-regulated protein, 78kDa), T-complex, Chaperon in containing TCP1; subunit 7 (beta) and subunit 4 (delta) and subunit 2 (beta), have been introduced as hub-bottlnecks proteins. HSP90AA1, MKKS, EZR, HSPA14, APOB and CAD have been determined as seed proteins. Conclusion: Chaperons have a bold presentation in curtail area in Network therefore these key proteins beside the other hubbottlneck proteins may be a suitable candidates biomarker panel for diagnosis, prognosis and treatment processes in celiac disease.

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    APA: Copy

    ZAMANIAN AZODI, MONA, PEYVANDI, HASSAN, ROSTAMI NEJAD, MOHAMMAD, SAFAEI, AKRAM, ROSTAMI, KAMRAN, VAFAEE, REZA, HEIDARI, MOHAMMAD HOSSEIN, HOSSEINI, MOSTAFA, & ZALI, MOHAMMAD REZA. (2016). Protein-protein interaction network of celiac disease (). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 9(4), 268-277. SID. https://sid.ir/paper/324851/en

    Vancouver: Copy

    ZAMANIAN AZODI MONA, PEYVANDI HASSAN, ROSTAMI NEJAD MOHAMMAD, SAFAEI AKRAM, ROSTAMI KAMRAN, VAFAEE REZA, HEIDARI MOHAMMAD HOSSEIN, HOSSEINI MOSTAFA, ZALI MOHAMMAD REZA. Protein-protein interaction network of celiac disease (). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2016;9(4):268-277. Available from: https://sid.ir/paper/324851/en

    IEEE: Copy

    MONA ZAMANIAN AZODI, HASSAN PEYVANDI, MOHAMMAD ROSTAMI NEJAD, AKRAM SAFAEI, KAMRAN ROSTAMI, REZA VAFAEE, MOHAMMAD HOSSEIN HEIDARI, MOSTAFA HOSSEINI, and MOHAMMAD REZA ZALI, “Protein-protein interaction network of celiac disease (),” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 9, no. 4, pp. 268–277, 2016, [Online]. Available: https://sid.ir/paper/324851/en

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