Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding

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ABDOLLAHI HAMED; ZAMANIAN AZODI MONA; HATAMI BEHZAD

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Journal Paper

Paper Information

Journal: Gastroenterology and Hepatology From Bed to Bench Year:2017 | Volume:10 | Issue:Suppl 1 Page(s): 146-153

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Information Journal Paper

Title

Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding

Author(s)

ABDOLLAHI HAMED | ZAMANIAN AZODI MONA | HATAMI BEHZAD | Issue Writer Certificate

Keywords

Protein-protein interaction network analysis

Rat Model

None alcoholic fatty liver disease

Gene expression profile

Centrality analysis

Gene ontology

Abstract

Aim: This study investigates the effect of fat diet on Gene expression profile in rat liver via protein-protein interaction mapping analysis. Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition of liver in the world. This progressive metabolic disease is representative with fat accumulation in the patients’ liver that can led to advance stages, namely, cirrhosis and eventually cancer. Methods: Differentially expressed genes of NAFLD rat liver after 2, 4 and 6 weeks fat diet feeding were analyzed via GEO2R and protein-protein interaction network by Cytoscape v3. 6. 0. and the related plug-ins. The important genes were assigned based on degree and betweenness Centrality analysis and enriched using ClueGO+CluePedia Plug-in. Results: GAPDH, PRDM10, TP53, AKT1, INS, ALB, SRC, MAPK1, ACLY, ACACA, DECR1, ACACB, MBOAT4, TNF, EHHADH and JUN genes were introduced as key genes related to the fat diet fed NAFLD rats. Fatty acid biosynthesis and four other terms were introduced as the main related ones to the essential genes. Conclusion: The introduced critical genes and the related terms may describe NAFLD molecular condition and its progression to the other severe metabolic diseases. Moreover, these potential biomarkers may be monitored for diagnosis and treatment approaches after validation investigations.

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APA: Copy

ABDOLLAHI, HAMED, ZAMANIAN AZODI, MONA, & HATAMI, BEHZAD. (2017). Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(Suppl 1), 146-153. SID. https://sid.ir/paper/324899/en

Vancouver: Copy

ABDOLLAHI HAMED, ZAMANIAN AZODI MONA, HATAMI BEHZAD. Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(Suppl 1):146-153. Available from: https://sid.ir/paper/324899/en

IEEE: Copy

HAMED ABDOLLAHI, MONA ZAMANIAN AZODI, and BEHZAD HATAMI, “Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. Suppl 1, pp. 146–153, 2017, [Online]. Available: https://sid.ir/paper/324899/en

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