Identification of differentially-expressed of Olfactomedin-related proteins 4 and COL11A1 in Iranian patients with intestinal gastric cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Dabiri Asma; BAGHAEI KAVEH; HASHEMI MEHRDAD; Sadravi Shekoofeh; Malekpour Habib; LAHMI FARHAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Gastroenterology and Hepatology From Bed to Bench Year:2017 | Volume:10 | Issue:Suppl 1 Page(s): 62-69

Download Full-Text

View:

196

Download:

Cites:

Information Journal Paper

Title

Identification of differentially-expressed of Olfactomedin-related proteins 4 and COL11A1 in Iranian patients with intestinal gastric cancer

Author(s)

Keywords

Olfactomedin

Gastric cancer

COL11A1

Abstract

Aim: Due to limited information on these genes and to a better understanding of common biomarkers associated with cancer of the digestive tract routes, we aim to evaluated expression level of Olfactomedin4 (OLFM4) and (pro)collagen11A1/COL11A1 genes in people with Gastric cancer in Iran. Background: Gastric cancer is one of the main cause of cancer death. The early prognosis of Gastric cancer is still a matter of debate. Human Olfactomedin4 (OLFM4) is a glycoprotein that generally known as the antiapoptotic protein. (pro) collagen11A1/COL11A1 codes for the alpha-1 subunit of type XI collagen which exists in extracellular minor fibrillar collagen. In most cases, OLFM4 and COL11A1 are found to be up-regulated in many types of human cancers including Gastric cancer. Methods: 35 tissue samples were collected including 25 sample of patients with intestinal Gastric cancer and 10 healthy controls. Expression level of OLFM4 and COL11A1 genes identified by using RGQ software. For analysis of real time-PCR products, Rotor-Gene Q series software was used. Results: Our finding showed that expression level of OLFM4 was significantly upregulated and COL11A1 did not show any significant difference in expression level in Iranian population with Gastric cancer samples compared with those in normal samples. Conclusion: The results recommend that expression profiling of OLFM4 can be used for diagnosis of Gastric cancer, and OLFM4 seems to be used as a biomarker for the diagnosis of Gastric cancer. Regarding to our result, unlike some studies, COL11A1 did not show any significant difference between normal and tumor tissue which could explain ethological role in distribution of Gastric cancer.

Cites

No record.

References

No record.

Cite

APA: Copy

Dabiri, Asma, BAGHAEI, KAVEH, HASHEMI, MEHRDAD, Sadravi, Shekoofeh, Malekpour, Habib, & LAHMI, FARHAD. (2017). Identification of differentially-expressed of Olfactomedin-related proteins 4 and COL11A1 in Iranian patients with intestinal gastric cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(Suppl 1), 62-69. SID. https://sid.ir/paper/324900/en

Vancouver: Copy

Dabiri Asma, BAGHAEI KAVEH, HASHEMI MEHRDAD, Sadravi Shekoofeh, Malekpour Habib, LAHMI FARHAD. Identification of differentially-expressed of Olfactomedin-related proteins 4 and COL11A1 in Iranian patients with intestinal gastric cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(Suppl 1):62-69. Available from: https://sid.ir/paper/324900/en

IEEE: Copy

Asma Dabiri, KAVEH BAGHAEI, MEHRDAD HASHEMI, Shekoofeh Sadravi, Habib Malekpour, and FARHAD LAHMI, “Identification of differentially-expressed of Olfactomedin-related proteins 4 and COL11A1 in Iranian patients with intestinal gastric cancer,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. Suppl 1, pp. 62–69, 2017, [Online]. Available: https://sid.ir/paper/324900/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops