مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Evaluation of promoter methylation status of MLH1 gene in Iranian patients with colorectal tumors and adenoma polyps

Pages

  117-121

Abstract

 Aim: The aim of this study was to evaluate the methylation status of the promoter region of MLH1 gene in colorectal cancer (CRC) and its precursor lesions as well as elucidate its association with various clinicopathological characteristics among Iranian population. Background: Epigenetic silencing of mismatch repair genes, such as MLH1, by methylation of CpG islands of their promoter region has been proved to be an important mechanism in colorectal carcinogenesis. Methods: Fifty colorectal cancer and polyp tissue samples including 13 Primary colorectal tumor and 37 Adenoma polyp samples were enrolled in this study. Methylation-specific polymerase chain reaction (MSP) was performed to find the frequency of MLH1 Promoter methylation. Results: Promoter methylation of MLH1 gene was detected in 5 out of 13 tumor tissues and 4 out of 37 adenoma polyp. The frequency of MLH1 methylation in tumor samples was significantly higher compared to that in polyp tissues (P= 0. 026). No significant association was observed between MLH1 Promoter methylation and clinicopathological characteristics of the patients. Conclusion: The frequency of MLH1 Promoter methylation in CRC and colon polyp was 18%. Our findings indicated that methylation of MLH1 promoter region alone cannot be considered as a biomarker for early detection of CRC.

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    APA: Copy

    Zarandi, Ashkan, IRANI, SHIVA, Savabkar, Sanaz, Chaleshi, Vahid, Ghavideldarestani, Maryam, MIRFAKHRAIE, REZA, KHODADOOSTAN, MAHSA, NAZEMALHOSSEINI MOJARAD, EHSAN, & ASADZADEH AGHDAEI, HAMID. (2017). Evaluation of promoter methylation status of MLH1 gene in Iranian patients with colorectal tumors and adenoma polyps. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(Suppl 1), 117-121. SID. https://sid.ir/paper/324905/en

    Vancouver: Copy

    Zarandi Ashkan, IRANI SHIVA, Savabkar Sanaz, Chaleshi Vahid, Ghavideldarestani Maryam, MIRFAKHRAIE REZA, KHODADOOSTAN MAHSA, NAZEMALHOSSEINI MOJARAD EHSAN, ASADZADEH AGHDAEI HAMID. Evaluation of promoter methylation status of MLH1 gene in Iranian patients with colorectal tumors and adenoma polyps. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(Suppl 1):117-121. Available from: https://sid.ir/paper/324905/en

    IEEE: Copy

    Ashkan Zarandi, SHIVA IRANI, Sanaz Savabkar, Vahid Chaleshi, Maryam Ghavideldarestani, REZA MIRFAKHRAIE, MAHSA KHODADOOSTAN, EHSAN NAZEMALHOSSEINI MOJARAD, and HAMID ASADZADEH AGHDAEI, “Evaluation of promoter methylation status of MLH1 gene in Iranian patients with colorectal tumors and adenoma polyps,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. Suppl 1, pp. 117–121, 2017, [Online]. Available: https://sid.ir/paper/324905/en

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