High expression of Snail1 is associated with EMAST and poor prognosis in CRC patients

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Mohammadpour Somayeh; Torshizi Esfahani Amir; Bakhshian Farbod; MORTAZAVI TABATABAEI SEYED ABDOLREZA; Laleh Asma; NAZEMALHOSSEINI MOJARAD EHSAN

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2019 | Volume:12 | Issue:suppl 1 Page(s): 30-36

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Title

High expression of Snail1 is associated with EMAST and poor prognosis in CRC patients

Author(s)

Keywords

Snail1

Elevated microsatellite alteration at selected tetranucleotide repeats (EMAST)

Survival

Colorectal cancer

Abstract

Aim: This study aimed to determine the link between Snail1 expression and CRC patients’ Survival as well as its significant association with EMAST status. Background: Snail1 is an evolutionary preserved zinc-finger transcription protein which contributes to Epithelial-to-mesenchymal transition (EMT). EMT initiates invasion and proliferation in many tumors. Elevated microsatellite alteration at selected tetranucleotide repeats (EMAST) is a marker of poor prognosis in patients with Colorectal cancer (CRC). We hypothesized that Snail1 overexpression is an important mediator of metastasis and decreased Survival in CRCs that characteristically have EMAST phenotype. Methods: Quantitative real-time polymerase chain reactions were carried out to analyze the expression levels of Snail1 in both normal and tumor specimens from a total of 122 paraffin-embedded tissues (FFPE) of CRC sample with known EMAST status. The correlation between Snail1 expression and clinicopathological characteristics, Survival, and EMAST status were examined. Results: Snail1 overexpression was detected in tumor tissues in 32% of all examined patients and its positive expression was related to metastasis (p=0. 001) and EMAST+ phenotype (P=0. 017). Further, positive Snail1 expression correlates with poor overall Survival in CRC patients (P=0. 01). Conclusion: Our findings suggest that Snail1 overexpression is not only associated with EMAST but also with clinicopathological variables of poor prognosis. These results indicate that Snail1 expression levels may be useful for establishing novel therapeutic strategies and could help Survival improvement in CRC patients.

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APA: Copy

Mohammadpour, Somayeh, Torshizi Esfahani, Amir, Bakhshian, Farbod, MORTAZAVI TABATABAEI, SEYED ABDOLREZA, Laleh, Asma, & NAZEMALHOSSEINI MOJARAD, EHSAN. (2019). High expression of Snail1 is associated with EMAST and poor prognosis in CRC patients. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 12(suppl 1), 30-36. SID. https://sid.ir/paper/324954/en

Vancouver: Copy

Mohammadpour Somayeh, Torshizi Esfahani Amir, Bakhshian Farbod, MORTAZAVI TABATABAEI SEYED ABDOLREZA, Laleh Asma, NAZEMALHOSSEINI MOJARAD EHSAN. High expression of Snail1 is associated with EMAST and poor prognosis in CRC patients. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2019;12(suppl 1):30-36. Available from: https://sid.ir/paper/324954/en

IEEE: Copy

Somayeh Mohammadpour, Amir Torshizi Esfahani, Farbod Bakhshian, SEYED ABDOLREZA MORTAZAVI TABATABAEI, Asma Laleh, and EHSAN NAZEMALHOSSEINI MOJARAD, “High expression of Snail1 is associated with EMAST and poor prognosis in CRC patients,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. suppl 1, pp. 30–36, 2019, [Online]. Available: https://sid.ir/paper/324954/en

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