Predication of hub target genes of differentially expressed microRNAs contributing to Helicobacter pylori infection in gastric non-cancerous tissue

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NOROUZINIA MOHSEN; ZAMANIAN AZODI MONA; Najafgholizadeh Seyfi Diba; Kardan Ali; AKBARI ZAHRA

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2019 | Volume:12 | Issue:suppl 1 Page(s): 44-50

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Title

Predication of hub target genes of differentially expressed microRNAs contributing to Helicobacter pylori infection in gastric non-cancerous tissue

Author(s)

Keywords

MicroRNA

Helicobacter pylori

Regulatory network

Target genes

Hubs

Functional analysis

Abstract

Aim: The main goal of this investigation was to provide an overview on H. pylori effect on gastric tissue via bioinformatics analysis of microarray-identified miRNAs and its Target genes. Background: MicroRNAs which control about 30 to 60% of gene expression in human body play a critical role in different cell growth stages. Expression modification of non-coding (NC) RNAs in H. pylori infections requires further investigations to provide better understanding of their roles in the body. Methods: GSE54397, the MicroRNA microarray dataset, was analyzed by GEO2R, the online GEO database for detection of differentially expressed MicroRNAs and lastly the potential Target genes as well as their associated pathways. Results: A total of 244 miRNAs were detected as differentially expressed (p<0. 05 and FC>2) in non-cancerous tissue of gastric with H. pylori infection in comparison with tissues without H. pylori infection. The findings indicated that hub MicroRNAs and Target genes of up-regulated network are KIF9, DCTN3, and CA5BP1 along with hsa-miR-519d, hsa-miR-573, hsa-miR-646, hsa-miR-92a-1, hsamiR-186, and hsa-miR-892a, respectively. For the down-regulated network, genes of RABGAP1, HSPB11 and MicroRNAs of hsamiR-620, hsa-miR-19b-2, hsa-miR-555, and hsa-let-7f-2 were Hubs. Most of the up-regulated MicroRNAs are involved in gastric cancer development while there is no evidence for the down-regulated ones. Yet, all of the hub down-regulated miRNAs are reported to have associations with different kinds of cancer. Conclusion: The introduced hub miRNAs and genes may serve as feasible markers in the mechanisms of H. pylori infection for different kinds of gastric diseases, in particular gastric cancer. However, their role requires further investigations.

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APA: Copy

NOROUZINIA, MOHSEN, ZAMANIAN AZODI, MONA, Najafgholizadeh Seyfi, Diba, Kardan, Ali, & AKBARI, ZAHRA. (2019). Predication of hub target genes of differentially expressed microRNAs contributing to Helicobacter pylori infection in gastric non-cancerous tissue. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 12(suppl 1), 44-50. SID. https://sid.ir/paper/324961/en

Vancouver: Copy

NOROUZINIA MOHSEN, ZAMANIAN AZODI MONA, Najafgholizadeh Seyfi Diba, Kardan Ali, AKBARI ZAHRA. Predication of hub target genes of differentially expressed microRNAs contributing to Helicobacter pylori infection in gastric non-cancerous tissue. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2019;12(suppl 1):44-50. Available from: https://sid.ir/paper/324961/en

IEEE: Copy

MOHSEN NOROUZINIA, MONA ZAMANIAN AZODI, Diba Najafgholizadeh Seyfi, Ali Kardan, and ZAHRA AKBARI, “Predication of hub target genes of differentially expressed microRNAs contributing to Helicobacter pylori infection in gastric non-cancerous tissue,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. suppl 1, pp. 44–50, 2019, [Online]. Available: https://sid.ir/paper/324961/en

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