Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ghorbaninejad Mahsa; Heydari Raheleh; MOHAMMADI PARVANEH; SHAHROKH SHABNAM; HAGHAZALI MEHRDAD; Khanabadi Binazir; MEYFOUR ANNA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Gastroenterology and Hepatology From Bed to Bench Year:2019 | Volume:12 | Issue:suppl 1 Page(s): 80-86

Download Full-Text

View:

120

Download:

Cites:

Information Journal Paper

Title

Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis

Author(s)

Keywords

Ulcerative colitis

TNF-α

NOTCH signaling

HES1

Abstract

Aim: The aim of this study was to determine gene expression levels of TNF-α , NOTCH1, and HES1 in patients with UC. Background: Intestinal inflammation and epithelial injury are the leading actors of inflammatory bowel disease (IBD), causing an excessive expression of pro-inflammatory cytokines such as TNF-α . Also, target genes of NOTCH signaling are involved in the regulation of intestinal homeostasis. Previous studies have demonstrated that TNF-α increases in Ulcerative colitis (UC) patients, but the relationship between TNF-α and NOTCH signaling pathway in UC etiopathology needs further study. Methods: Twelve active UC patients and twelve healthy controls were enrolled in this study. RNA was extracted and the mRNA expression levels of TNF-α , NOTCH1, and HES1 were examined using real-time PCR analyses. Further, transcriptome data deposited in Gene Expression Omnibus (GEO) database were analyzed to detect the differential expression of TNF superfamily and NOTCH1 gene in IBD patients. Finally, the interaction of TNF-α and NOTCH signaling was obtained from The SIGnaling Network Open Resource 2. 0 (SIGNOR 2. 0) database. Results: The transcription levels of TNF-α , NOTCH1, and HES1 genes were significantly elevated in UC patients compared with control (p < 0. 05). In addition, GEO results confirmed our expression results. SIGNOR analysis showed that TNF-α interacts with NOTCH signaling components. Conclusion: Based on our data, we observed that NOTCH1 and HES1 in co-operation of TNF-α , may play an important role in pathogenesis of UC. The members of NOTCH signaling pathway can be ideal candidates to target the therapy of IBD.

Cites

No record.

References

No record.

Cite

APA: Copy

Ghorbaninejad, Mahsa, Heydari, Raheleh, MOHAMMADI, PARVANEH, SHAHROKH, SHABNAM, HAGHAZALI, MEHRDAD, Khanabadi, Binazir, & MEYFOUR, ANNA. (2019). Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 12(suppl 1), 80-86. SID. https://sid.ir/paper/324963/en

Vancouver: Copy

Ghorbaninejad Mahsa, Heydari Raheleh, MOHAMMADI PARVANEH, SHAHROKH SHABNAM, HAGHAZALI MEHRDAD, Khanabadi Binazir, MEYFOUR ANNA. Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2019;12(suppl 1):80-86. Available from: https://sid.ir/paper/324963/en

IEEE: Copy

Mahsa Ghorbaninejad, Raheleh Heydari, PARVANEH MOHAMMADI, SHABNAM SHAHROKH, MEHRDAD HAGHAZALI, Binazir Khanabadi, and ANNA MEYFOUR, “Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. suppl 1, pp. 80–86, 2019, [Online]. Available: https://sid.ir/paper/324963/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops