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Information Journal Paper

Title

Effects of high fat medium conditions on cellular gene expression profile: a network analysis approach

Pages

  130-135

Abstract

 Aim: This study aimed to evaluate high fat medium (HFM) effect on the Gene expression profile of human Sk-hep1 cells and to determine critical differential proteins. Background: There is a correlation between high fat diet (HFD), obesity, and non-alcoholic fatty liver disease. Despite wide range of investigations, understanding molecular mechanism of HFD effect on onset and progression of NAFLD warrants further examination. In this study, network analysis is applied to obtain a clear perspective about HFD effects and NAFLD. Methods: Gene expression profiles of human Sk-hep1 cells treated with HFM versus controls were extracted from GEO. Data were analyzed by GEO2R where the significant and characterized DEGs were included in the PPI network. The top 10 nodes of query DEGs based on four centrality parameters were selected to determine central nodes. The common hub nodes with at least other one central group were identified as central nodes. Action map was provided for the introduced central nodes. Results: Heterogeneous nuclear ribonucleoprotein family including A1, A2/B1, D, R, and D-like, and five proteins (PRPF40A, SRSF1, PCF11, LSM8, and HSP90AA1) were introduced as differential proteins. Conclusion: mRNA processing and several biological terms including hypoxia and oxidative stress, apoptosis, regulation of cell morphology and cytoskeletal organization, and differentiation of micro tubes were introduced as dysregulated terms under HFM condition.

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    APA: Copy

    ASADZADEH AGHDAEI, HAMID, Zadeh Esmaeel, Mohammad Mehdi, ESMAEILI, SOMAYEH, REZAEI TAVIRANI, MOSTAFA, Rezaei Tavirani, Sina, MANSOURI, VAHID, & MONTAZER, FATEMEH. (2019). Effects of high fat medium conditions on cellular gene expression profile: a network analysis approach. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 12(suppl 1), 130-135. SID. https://sid.ir/paper/324965/en

    Vancouver: Copy

    ASADZADEH AGHDAEI HAMID, Zadeh Esmaeel Mohammad Mehdi, ESMAEILI SOMAYEH, REZAEI TAVIRANI MOSTAFA, Rezaei Tavirani Sina, MANSOURI VAHID, MONTAZER FATEMEH. Effects of high fat medium conditions on cellular gene expression profile: a network analysis approach. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2019;12(suppl 1):130-135. Available from: https://sid.ir/paper/324965/en

    IEEE: Copy

    HAMID ASADZADEH AGHDAEI, Mohammad Mehdi Zadeh Esmaeel, SOMAYEH ESMAEILI, MOSTAFA REZAEI TAVIRANI, Sina Rezaei Tavirani, VAHID MANSOURI, and FATEMEH MONTAZER, “Effects of high fat medium conditions on cellular gene expression profile: a network analysis approach,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. suppl 1, pp. 130–135, 2019, [Online]. Available: https://sid.ir/paper/324965/en

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