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Information Journal Paper

Title

PHOTODYNAMIC THERAPY WITH BENGAL ROSE AND DERIVATIVES AGAINST LEISHMANIA AMAZONENSIS

Pages

  46-50

Abstract

 Introduction: The treatment of CUTANEOUS LEISHMANIASIS (CL) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. PHOTODYNAMIC THERAPY (PDT) is an alternative for the treatment of CL, and some xanthene dyes have the potential for use in PDT.Methods: The XANTHENES ROSE BENGAL B (RB) and its derivatives rose bengal methyl ester (RBMET), and butyl ester (RBBUT) were analyzed for leishmanicidal activity against promastigotes and intracellular amastigotes of LEISHMANIA AMAZONENSIS. Cytotoxicity was assessed in J774.A1 macrophages.Results: RB derivates RBMET (IC50 9.83 μM), and RBBUT (IC50 45.08 μM) showed leishmanicidal activity, however, were toxic to J774.A1 macrophages, resulting in low selectivity index.Conclusion: The RBMET and RBBUT showed to be effective against the L. amazonensis and the low selectivity index presented may not be a limitation for their use in PDT to CL treatment.

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    APA: Copy

    NAVASCONI, TAISA ROCHA, DOS REIS, VANESSA NESI, FREITAS, CAMILA FABIANO, PEREIRA, PAULO CESAR DE SOUZA, HIOKA, NOBORU, CAMPANA LONARDONI, MARIA VALDRINEZ, ALESSI ARISTIDES, SANDRA MARA, & VERZIGNASSI SILVEIRA, THAIS GOMES. (2017). PHOTODYNAMIC THERAPY WITH BENGAL ROSE AND DERIVATIVES AGAINST LEISHMANIA AMAZONENSIS. JOURNAL OF LASERS IN MEDICAL SCIENCES, 8(1), 46-50. SID. https://sid.ir/paper/325943/en

    Vancouver: Copy

    NAVASCONI TAISA ROCHA, DOS REIS VANESSA NESI, FREITAS CAMILA FABIANO, PEREIRA PAULO CESAR DE SOUZA, HIOKA NOBORU, CAMPANA LONARDONI MARIA VALDRINEZ, ALESSI ARISTIDES SANDRA MARA, VERZIGNASSI SILVEIRA THAIS GOMES. PHOTODYNAMIC THERAPY WITH BENGAL ROSE AND DERIVATIVES AGAINST LEISHMANIA AMAZONENSIS. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2017;8(1):46-50. Available from: https://sid.ir/paper/325943/en

    IEEE: Copy

    TAISA ROCHA NAVASCONI, VANESSA NESI DOS REIS, CAMILA FABIANO FREITAS, PAULO CESAR DE SOUZA PEREIRA, NOBORU HIOKA, MARIA VALDRINEZ CAMPANA LONARDONI, SANDRA MARA ALESSI ARISTIDES, and THAIS GOMES VERZIGNASSI SILVEIRA, “PHOTODYNAMIC THERAPY WITH BENGAL ROSE AND DERIVATIVES AGAINST LEISHMANIA AMAZONENSIS,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 8, no. 1, pp. 46–50, 2017, [Online]. Available: https://sid.ir/paper/325943/en

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