مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PROTEOMIC ANALYSIS OF THE EFFECT OF EXTREMELY LOW- FREQUENCY ELECTROMAGNETIC FIELDS (ELF-EMF) WITH DIFFERENT INTENSITIES IN SH-SY5Y NEUROBLASTOMA CELL LINE

Pages

  79-83

Abstract

 Introduction: During the last 3 decades, human is exposed to extremely low frequency electromagnetic fields (ELF-EMF) emitted by power lines and electronic devices. It is now well accepted that ELF-EMF are able to produce a variety of biological effects, although the molecular mechanism is unclear and controversial. Investigation of different intensities effects of 50 Hz ELF-EMF on cell morphology and PROTEIN EXPRESSION is the aim of this study.Methods: SH-SY5Y human NEUROBLASTOMA cell line was exposed to 0.5 and 1 mT 50 Hz (ELF-EMF) for 3 hours. PROTEOMICS techniques were used to determine the effects of these fields on PROTEIN EXPRESSION. Bioinformatic and statistical analysis of proteomes were performed using Progensis SameSpots software.Results: Our results showed that exposure to ELF-EMF changes cell morphology and induces a dose- dependent decrease in the proliferation rate of the cells. The proteomic studies and bioinformatic analysis indicate that exposure to 50 Hz ELF-EMF leads to alteration of cell PROTEIN EXPRESSION in both dose-dependent and INTENSITY dependent manner, but the later is more pronounced.Conclusion: Our data suggests that increased INTENSITY of ELF-EMF may be associated with more alteration in cell PROTEIN EXPRESSION, as well as effect on cell morphology and proliferation.

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    APA: Copy

    REZAIE TAVIRANI, MOSTAFA, HASANZADEH, HADI, SEYYEDI, SAMANEH, & ZALI, HAKIMEH. (2017). PROTEOMIC ANALYSIS OF THE EFFECT OF EXTREMELY LOW- FREQUENCY ELECTROMAGNETIC FIELDS (ELF-EMF) WITH DIFFERENT INTENSITIES IN SH-SY5Y NEUROBLASTOMA CELL LINE. JOURNAL OF LASERS IN MEDICAL SCIENCES, 8(2), 79-83. SID. https://sid.ir/paper/325967/en

    Vancouver: Copy

    REZAIE TAVIRANI MOSTAFA, HASANZADEH HADI, SEYYEDI SAMANEH, ZALI HAKIMEH. PROTEOMIC ANALYSIS OF THE EFFECT OF EXTREMELY LOW- FREQUENCY ELECTROMAGNETIC FIELDS (ELF-EMF) WITH DIFFERENT INTENSITIES IN SH-SY5Y NEUROBLASTOMA CELL LINE. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2017;8(2):79-83. Available from: https://sid.ir/paper/325967/en

    IEEE: Copy

    MOSTAFA REZAIE TAVIRANI, HADI HASANZADEH, SAMANEH SEYYEDI, and HAKIMEH ZALI, “PROTEOMIC ANALYSIS OF THE EFFECT OF EXTREMELY LOW- FREQUENCY ELECTROMAGNETIC FIELDS (ELF-EMF) WITH DIFFERENT INTENSITIES IN SH-SY5Y NEUROBLASTOMA CELL LINE,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 8, no. 2, pp. 79–83, 2017, [Online]. Available: https://sid.ir/paper/325967/en

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