PHOTOBIOMODULATION THERAPY – AN INNOVATIVE APPROACH TO PRECISION PHOTOMEDICINE FOR REGENERATIVE THERAPIES WITH ENDOGENOUS STEM CELLS

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ARANY PRAVEEN R.

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Journal Paper

Paper Information

Journal: JOURNAL OF LASERS IN MEDICAL SCIENCES Year:2018 | Volume:9 | Issue:SUPPL A (9TH WORLD CONGRESS OF SOLA) Page(s): 15-15

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Title

PHOTOBIOMODULATION THERAPY – AN INNOVATIVE APPROACH TO PRECISION PHOTOMEDICINE FOR REGENERATIVE THERAPIES WITH ENDOGENOUS STEM CELLS

Author(s)

ARANY PRAVEEN R.

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Abstract

The use of biophotonics devices has pervaded many aspects of clinical medicine from simple fiberoptics for lighting to high power lasers for precision surgery. Advances in our understanding of light-biological tissue interactions are leading innovative new applications. These include low dose biophotonics for various forms of therapy such as antimicrobial photodynamic therapy (PDT) and photobiomodulation (PBM) therapy. This latter modality has significant implications for future clinical dentistry given its broad impact on immunomodulation, analgesia, wound healing and tissue regeneration. This presentation will present our salient research findings over the past 2 decades that has focused on molecular mechanisms of PBM therapy.Our prior work observed a key role for the mediating of these biological responses and has uncovered a novel role of a latent growth factor, TGF-beta1, activation as one of the major extracellular mediators. We have noted a key role of an amino acid on the growth factor complex, a methionine at position 253 that acts as a redox sensor for the laser-generated ROS. Activation of this multi-faceted growth factor has potent biological implications for wound healing, immunomodulation and stem cell differentiation. This presentation will provide a brief overview of our work investigating these applications, specifically emphasizing the ability of PBM therapy to promote tissue regeneration by expansion and directed differentiation of stem cells from a wide range of anatomical niches such as bone marrow, skin and mucosa, and dental pulp.A major goal of our research group is to promote human clinical translation of PBM therapy. We have been examining the key physical (device) and biological (mechanisms) factors to promote the development of safe and effective clinical PBM protocols. While it is well established that phototoxicity at high doses results from thermal and excessive ROS, the precise molecular pathway had not been described.Our recent efforts have observed a key role of cell stress in the endoplasmic reticulum induced by PBM laser doses are mediated by a central photoreceptive factor, ATF-4 that makes critical cell survival versus cell death decisions.The practical implication of these studies is that ATF-4 can be used as a precise molecular biomarker to determine maximal PBM therapeutic dosing within the non-thermal regimen. This presentation will highlight these studies and our ongoing efforts to enable wider realization and acceptance of the tremendous potential of PBM therapy to revolutionize healthcare.

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APA: Copy

ARANY, PRAVEEN R.. (2018). PHOTOBIOMODULATION THERAPY – AN INNOVATIVE APPROACH TO PRECISION PHOTOMEDICINE FOR REGENERATIVE THERAPIES WITH ENDOGENOUS STEM CELLS. JOURNAL OF LASERS IN MEDICAL SCIENCES, 9(SUPPL A (9TH WORLD CONGRESS OF SOLA)), 15-15. SID. https://sid.ir/paper/326062/en

Vancouver: Copy

ARANY PRAVEEN R.. PHOTOBIOMODULATION THERAPY – AN INNOVATIVE APPROACH TO PRECISION PHOTOMEDICINE FOR REGENERATIVE THERAPIES WITH ENDOGENOUS STEM CELLS. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2018;9(SUPPL A (9TH WORLD CONGRESS OF SOLA)):15-15. Available from: https://sid.ir/paper/326062/en

IEEE: Copy

PRAVEEN R. ARANY, “PHOTOBIOMODULATION THERAPY – AN INNOVATIVE APPROACH TO PRECISION PHOTOMEDICINE FOR REGENERATIVE THERAPIES WITH ENDOGENOUS STEM CELLS,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 9, no. SUPPL A (9TH WORLD CONGRESS OF SOLA), pp. 15–15, 2018, [Online]. Available: https://sid.ir/paper/326062/en

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