Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease

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Malanotte Jessica Aline; Chasko Ribeiro Lucineia de Fatima; Peretti Ana Luiza; Martin Kakihata Camila Mayumi; Potulsky Andrey; Bittencourt Guimaraes Ana Tereza; Flor Bertolini Gladson Ricardo; Nassar Patricia Oehlmeyer; Nassar Carlos Augusto

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Journal: JOURNAL OF LASERS IN MEDICAL SCIENCES Year:2020 | Volume:11 | Issue:1 Page(s): 56-64

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Title

Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease

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Keywords

Low-level laser

Periodontitis

Inflammation

Sciatic nerve

Abstract

Introduction: Periodontal disease (PD) is an inflammatory condition, which leads to tooth loss and promotes a systemic inflammatory state that can aggravate the nerve degeneration. As laser therapy may stimulate regeneration, this study aimed to evaluate the effect of the Low-level laser (LLL) on peripheral nerve regeneration under the systemic inflammatory condition of PD. Methods: Thirry-two male rats were used, distributed in 4 groups: nerve injury (NIG); periodontal disease with nerve injury (PDNI); nerve injury and treatment (TNIG); periodontal disease with nerve injury and treatment (PDNIT). On the 7th day of the experiment, the animals had ligatures placed around the lower first molars. On the 22nd day, they underwent peripheral nerve damage, and on the 25th day, the LLL treatment was initiated, performed for two weeks. The sciatic functional index (SFI) was evaluated with subsequent euthanasia of all the animals on the 37th day of the experiment. The Sciatic nerve was collected for morphological and oxidative stress analysis and the hemi jaws for radiographic analysis. Results: Regarding the SFI, there was no difference among the groups in the first evaluation (EV) pre-injury; as for theEV2, after injury, all the groups presented a decrease in these values, which remained in post-treatment. For the morphology of the PDNI, nerve tissue presented larger diameter fibers, whereas, for NIT and PDNIT, fibers had smaller diameters with endoneurial organization. When it comes to the antioxidant system, there was an increase in protein concentration, higher superoxide activity, and decreased glutathione transferase activity in the treated groups. Catalase and cholinesterase did not differ between the groups, and lipoperoxidation (LPO) increased in the PD groups. For the mandible radiographic analysis, it was possible to verify the induction of PD. Conclusion: As for the used parameters, the Low-level laser was not effective in increasing the nociceptive threshold, but it contributed to the regeneration of nerve fibers, although the Inflammation was still present in the site. However, the treatment was effective in protecting cells against oxidative damage due to increased SOD and increased protein, although the decrease in GST demonstrates the inhibition of this stage of the antioxidant system.

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APA: Copy

Malanotte, Jessica Aline, Chasko Ribeiro, Lucineia de Fatima, Peretti, Ana Luiza, Martin Kakihata, Camila Mayumi, Potulsky, Andrey, Bittencourt Guimaraes, Ana Tereza, Flor Bertolini, Gladson Ricardo, Nassar, Patricia Oehlmeyer, & Nassar, Carlos Augusto. (2020). Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease. JOURNAL OF LASERS IN MEDICAL SCIENCES, 11(1), 56-64. SID. https://sid.ir/paper/326162/en

Vancouver: Copy

Malanotte Jessica Aline, Chasko Ribeiro Lucineia de Fatima, Peretti Ana Luiza, Martin Kakihata Camila Mayumi, Potulsky Andrey, Bittencourt Guimaraes Ana Tereza, Flor Bertolini Gladson Ricardo, Nassar Patricia Oehlmeyer, Nassar Carlos Augusto. Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2020;11(1):56-64. Available from: https://sid.ir/paper/326162/en

IEEE: Copy

Jessica Aline Malanotte, Lucineia de Fatima Chasko Ribeiro, Ana Luiza Peretti, Camila Mayumi Martin Kakihata, Andrey Potulsky, Ana Tereza Bittencourt Guimaraes, Gladson Ricardo Flor Bertolini, Patricia Oehlmeyer Nassar, and Carlos Augusto Nassar, “Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 11, no. 1, pp. 56–64, 2020, [Online]. Available: https://sid.ir/paper/326162/en

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