EFFECTS OF AQUEOUS SAFFRON EXTRACT (CROCUS SATIVUS L.) ON THE ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE

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HOSSEINZADEH HOSSEIN; IMENSHAHIDI MOHSEN; ARASTEH ALIREZA

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Journal: Avicenna Journal of Phytomedicine Year:2012 | Volume:2 | Issue:1 Page(s): 24-30

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Information Journal Paper

Title

EFFECTS OF AQUEOUS SAFFRON EXTRACT (CROCUS SATIVUS L.) ON THE ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE

Author(s)

HOSSEINZADEH HOSSEIN | IMENSHAHIDI MOHSEN | ARASTEH ALIREZA | Issue Writer Certificate

Keywords

AQUEOUS SAFFRON EXTRACT

CROCUS SATIVUS L.

CPP (CONDITIONED PLACE PREFERENCE)

MORPHINE

MICE

Abstract

Objective: In the present study, the effects of AQUEOUS SAFFRON EXTRACT (Crocus sativus L.) on the acquisition and reinstatement of MORPHINE-induced conditioned place preference (CPP) in MICE were investigated.Materials and Methods: Subcutaneous administration of MORPHINE (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for four days) 30 min before the MORPHINE administration decreased the acquisition of MORPHINE CPP. In other groups of animal, following extinction of a place preference induced by MORPHINE (40 mg/kg), single administration of MORPHINE (10 mg/kg) reinstated the place reference. The aqueous extract (80 mg/kg) 30 min before this priming dose of MORPHINE blocked MORPHINE-induced reinstatement of place preference.Results: These results show that AQUEOUS SAFFRON EXTRACT can reduce the acquisition and reinstatement of MORPHINE-induced conditioned place preference.

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APA: Copy

HOSSEINZADEH, HOSSEIN, IMENSHAHIDI, MOHSEN, & ARASTEH, ALIREZA. (2012). EFFECTS OF AQUEOUS SAFFRON EXTRACT (CROCUS SATIVUS L.) ON THE ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 2(1), 24-30. SID. https://sid.ir/paper/326239/en

Vancouver: Copy

HOSSEINZADEH HOSSEIN, IMENSHAHIDI MOHSEN, ARASTEH ALIREZA. EFFECTS OF AQUEOUS SAFFRON EXTRACT (CROCUS SATIVUS L.) ON THE ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2012;2(1):24-30. Available from: https://sid.ir/paper/326239/en

IEEE: Copy

HOSSEIN HOSSEINZADEH, MOHSEN IMENSHAHIDI, and ALIREZA ARASTEH, “EFFECTS OF AQUEOUS SAFFRON EXTRACT (CROCUS SATIVUS L.) ON THE ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 2, no. 1, pp. 24–30, 2012, [Online]. Available: https://sid.ir/paper/326239/en

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