EFFECT OF GANODERMA LUCIDUM HYDROALCOHOLIC EXTRACT ON INSULIN RELEASE IN RAT-ISOLATED PANCREATIC ISLETS

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SHAFIEE NICK REZA; PARIZADEH SEYYED MOHAMMAD REZA; ZOKAIE NONA; GHORBANI AHMAD

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Journal: Avicenna Journal of Phytomedicine Year:2012 | Volume:2 | Issue:4 Page(s): 206-211

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Title

EFFECT OF GANODERMA LUCIDUM HYDROALCOHOLIC EXTRACT ON INSULIN RELEASE IN RAT-ISOLATED PANCREATIC ISLETS

Author(s)

SHAFIEE NICK REZA | PARIZADEH SEYYED MOHAMMAD REZA | ZOKAIE NONA | GHORBANI AHMAD | Issue Writer Certificate

Keywords

GANODERMA LUCIDUM

INSULIN

ISOLATED ISLETS

RAT

Abstract

Objective: GANODERMA LUCIDUM (G. Lucidum) has been suggested to increase serum INSULIN level. This study was undertaken to investigate its direct effect on the islets of Langerhans.Material and Methods: Male albino Wistar RATs were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. The islets were incubated for 60 min in Krebs bicarbonate buffer containing 3 or 10 mM glucose in the presence of hydroalcoholic extract ofG. Lucidum (1 mg/ml), 3-isobutyl-1-methylxanthine (IBMX, 100 mM) or vehicle.Results: Exposure of islets to the extract increased INSULIN secretion at basal (3 mM) glucose concentration. Increase of glucose concentration to 10 mM resulted in a significant increase in the RATe of INSULIN secretion. While the IBMX could augment INSULIN release evoked by 10 mM glucose, the extract failed to modify it.Conclusion: Our results demonstrate that G. lucidum acts directly on the Langerhans islets to increase basal INSULIN release.

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APA: Copy

SHAFIEE NICK, REZA, PARIZADEH, SEYYED MOHAMMAD REZA, ZOKAIE, NONA, & GHORBANI, AHMAD. (2012). EFFECT OF GANODERMA LUCIDUM HYDROALCOHOLIC EXTRACT ON INSULIN RELEASE IN RAT-ISOLATED PANCREATIC ISLETS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 2(4), 206-211. SID. https://sid.ir/paper/326272/en

Vancouver: Copy

SHAFIEE NICK REZA, PARIZADEH SEYYED MOHAMMAD REZA, ZOKAIE NONA, GHORBANI AHMAD. EFFECT OF GANODERMA LUCIDUM HYDROALCOHOLIC EXTRACT ON INSULIN RELEASE IN RAT-ISOLATED PANCREATIC ISLETS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2012;2(4):206-211. Available from: https://sid.ir/paper/326272/en

IEEE: Copy

REZA SHAFIEE NICK, SEYYED MOHAMMAD REZA PARIZADEH, NONA ZOKAIE, and AHMAD GHORBANI, “EFFECT OF GANODERMA LUCIDUM HYDROALCOHOLIC EXTRACT ON INSULIN RELEASE IN RAT-ISOLATED PANCREATIC ISLETS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 2, no. 4, pp. 206–211, 2012, [Online]. Available: https://sid.ir/paper/326272/en

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