PROTECTIVE EFFECT OFHIBISCUS SABDARIFFA AGAINST SERUM/GLUCOSE DEPRIVATION-INDUCED PC12 CELLS INJURY

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BAKHTIARI ELHAM; HOSSEINI AZAR; MOUSAVI SEYED HADI

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Journal Paper

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Journal: Avicenna Journal of Phytomedicine Year:2015 | Volume:5 | Issue:3 Page(s): 231-237

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Title

PROTECTIVE EFFECT OFHIBISCUS SABDARIFFA AGAINST SERUM/GLUCOSE DEPRIVATION-INDUCED PC12 CELLS INJURY

Author(s)

BAKHTIARI ELHAM | HOSSEINI AZAR | MOUSAVI SEYED HADI | Issue Writer Certificate

Keywords

HIBISCUS SABDARIFFA

SGD

PC12 CELL

APOPTOSIS

Abstract

Objectives: Findings natural products with antioxidant and antiapoptotic properties has been one of the interesting challenges in the search for the treatment of neurodegenerative diseases including ischemic stroke. Serum/glucose deprivation (SGD) has been used as a model for the understanding of the molecular mechanisms of neuronal damage during ischemia in vitro and for the expansion of neuroprotective drugs against ischemia-induced brain injury. Recent studies showed that HIBISCUS SABDARIFFA exert pharmacological actions such as potent antioxidant. Therefore, in this study we investigated the protective effect of extract of H. sabdariffa against SGD-induced PC12 CELLs injury.Materials and Methods: Cells were pretreated with different concentrations of H. sabdariffa extract (HSE) for 2 hr, and then exposed to SGD condition for 6, 12 and 18 hr.Results: SGD caused a major reduction in cell viability after 6, 12, and 18 hr as compared with control cells (p<0.001). Pretreatment with HSE (30-500 mg/mL) significantly increased cell viability following SGD insult for 6, 12 and 18 hr. A significant increase in cell APOPTOSIS was seen in cells under SGD condition after 12hr as compared with control cells (p<0.001). Pretreatment with HSE significantly decreased cell APOPTOSIS subsequent SGD conditionafter12hr at concentration of 60, 125 and 250.Conclusion: These data showed that HSE had a protective property under SGD condition in PC12 CELLs, suggesting that H. sabdariffa has the potential to be used as a new therapeutic approach for neurodegenerative disorders.

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APA: Copy

BAKHTIARI, ELHAM, HOSSEINI, AZAR, & MOUSAVI, SEYED HADI. (2015). PROTECTIVE EFFECT OFHIBISCUS SABDARIFFA AGAINST SERUM/GLUCOSE DEPRIVATION-INDUCED PC12 CELLS INJURY. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 5(3), 231-237. SID. https://sid.ir/paper/326305/en

Vancouver: Copy

BAKHTIARI ELHAM, HOSSEINI AZAR, MOUSAVI SEYED HADI. PROTECTIVE EFFECT OFHIBISCUS SABDARIFFA AGAINST SERUM/GLUCOSE DEPRIVATION-INDUCED PC12 CELLS INJURY. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2015;5(3):231-237. Available from: https://sid.ir/paper/326305/en

IEEE: Copy

ELHAM BAKHTIARI, AZAR HOSSEINI, and SEYED HADI MOUSAVI, “PROTECTIVE EFFECT OFHIBISCUS SABDARIFFA AGAINST SERUM/GLUCOSE DEPRIVATION-INDUCED PC12 CELLS INJURY,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 5, no. 3, pp. 231–237, 2015, [Online]. Available: https://sid.ir/paper/326305/en

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