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Information Journal Paper

Title

THE EFFECTS OF DIFFERENT FRACTIONS OF CORIANDRUM SATIVUM ON PENTYLENETETRAZOLE-INDUCED SEIZURES AND BRAIN TISSUES OXIDATIVE DAMAGE IN RATS

Pages

  223-235

Abstract

 Objective: In the present work, the effects of different FRACTIONS of CORIANDRUM SATIVUM (C. sativum), on PENTYLENETETRAZOLE (PTZ)-induced SEIZURES and brain tissues oxidative damage were investigated in rats.Materials and Methods: The rats were divided into the following groups: (1) vehicle, (2) PTZ (90 mg/kg), (3) water fraction (WF) of C. sativum (25 and 100 mg/kg), (4) n-butanol fraction (NBF) of C. sativum (25 and 100 mg/kg), and (5) ethyl acetate fraction (EAF) of C. sativum (25 and 100 mg/kg).Results: The first generalized tonic-clonic SEIZURES (GTCS) latency in groups treated with 100 mg /kg of WF or EAF was significantly higher than that of PTZ group (p<0.01). In contrast to WF, the EAF and NBF were not effective in increasing the first minimal clonic seizure (MCS) latency. Malondialdehyde (MDA) levels in both cortical and hippocampal tissues of PTZ group were significantly higher than those of control animals (p<0.001). Pretreatment with WF, NBF, or EAF resulted in a significant reduction in the MDA levels of hippocampi (p<0.01 - p<0.001). Following PTZ administration, a significant reduction in total thiol groups was observed in the brain tissues (p<0.05). Pretreatment with WF and NBF significantly elevated thiol concentrations in cortical and hippocampal tissues, respectively (p<0.05).Conclusion: The present study showed that different FRACTIONS of C. sativum possess antioxidant activity in the brain and WF and EAF of this plant have anticonvulsant effects.

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    APA: Copy

    ANAEIGOUDARI, AKBAR, HOSSEINI, MAHMOUD, KARAMI, REZA, VAFAEE, FARZANEH, MOHAMMADPOUR, TOKTAM, GHORBANI, AHMAD, & SADEGHNIA, HAMID REZA. (2016). THE EFFECTS OF DIFFERENT FRACTIONS OF CORIANDRUM SATIVUM ON PENTYLENETETRAZOLE-INDUCED SEIZURES AND BRAIN TISSUES OXIDATIVE DAMAGE IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(2), 223-235. SID. https://sid.ir/paper/326338/en

    Vancouver: Copy

    ANAEIGOUDARI AKBAR, HOSSEINI MAHMOUD, KARAMI REZA, VAFAEE FARZANEH, MOHAMMADPOUR TOKTAM, GHORBANI AHMAD, SADEGHNIA HAMID REZA. THE EFFECTS OF DIFFERENT FRACTIONS OF CORIANDRUM SATIVUM ON PENTYLENETETRAZOLE-INDUCED SEIZURES AND BRAIN TISSUES OXIDATIVE DAMAGE IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(2):223-235. Available from: https://sid.ir/paper/326338/en

    IEEE: Copy

    AKBAR ANAEIGOUDARI, MAHMOUD HOSSEINI, REZA KARAMI, FARZANEH VAFAEE, TOKTAM MOHAMMADPOUR, AHMAD GHORBANI, and HAMID REZA SADEGHNIA, “THE EFFECTS OF DIFFERENT FRACTIONS OF CORIANDRUM SATIVUM ON PENTYLENETETRAZOLE-INDUCED SEIZURES AND BRAIN TISSUES OXIDATIVE DAMAGE IN RATS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 2, pp. 223–235, 2016, [Online]. Available: https://sid.ir/paper/326338/en

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