GINGER EXTRACT MODULATES THE EXPRESSION OF IL-12 AND TGF-βIN THE CENTRAL NERVOUS SYSTEM AND SERUM OF MICE WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

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JAFARZADEH ABDOLLAH; AHANGAR PARVIN REYHANE; NEMATI MARYAM; TAGHIPOUR ZAHRA; SHAMSIZADEH ALI; AYOOBI FATEMEH; ZUHAIR MOHAMMAD HASSAN

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Journal: Avicenna Journal of Phytomedicine Year:2017 | Volume:7 | Issue:1 Page(s): 54-65

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Title

GINGER EXTRACT MODULATES THE EXPRESSION OF IL-12 AND TGF-βIN THE CENTRAL NERVOUS SYSTEM AND SERUM OF MICE WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

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Keywords

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

GINGER

IL-12

TGF-β

SERUM

Abstract

Objective: The main function of IL-12 is differentiation of naive T cells intoTh1 cells and TGF-b is a powerful immunoregulatory cytokine. The immunomodulatory and anti-inflammatory properties of GINGER have also been reported in some studies. The aim of this study was to evaluate the effects of GINGER extract on the expression of IL-12 and TGF-b in a model of EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE).Materials and Methods: EAE was induced in C57BL/6 mice by immunization with myelin oligodendroglial glycoprotein emulsified in complete Freund's adjuvant. The mice were administered intra-peritoneally with GINGER extracts or PBS, from day+3 to+30. On day 31, mice were scarified and the expression of IL-12 and TGF-b mRNA in the spinal cord were determined by using real time-PCR. The SERUM levels of cytokines were measured by ELISA.Results: In PBS-treated EAE mice, the expression of IL-12 P35 and IL-12 P40 mRNA in the CNS and the mean SERUM levels of IL-12 were significantly higher than those of healthy group (p<0.001). In GINGER-treated EAE mice, the expression of IL-12 mRNA and its SERUM levels were significantly lower as compared to PBS-treated EAE mice. No significant difference was observed between PBS-treated EAE mice and healthy group regarding the expression of TGF-b mRNA. In GINGER (300 mg/kg) -treated EAE group, the expression of TGF-b mRNA and its SERUM levels were significantly higher in comparison to PBS-treated EAE mice (p<0.01 and p<0.05, respectively).Conclusion: These results indicated that GINGER extract modulates the expression of IL-12 and TGF-b in CNS and SERUM of EAE mice.

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APA: Copy

JAFARZADEH, ABDOLLAH, AHANGAR PARVIN, REYHANE, NEMATI, MARYAM, TAGHIPOUR, ZAHRA, SHAMSIZADEH, ALI, AYOOBI, FATEMEH, & ZUHAIR, MOHAMMAD HASSAN. (2017). GINGER EXTRACT MODULATES THE EXPRESSION OF IL-12 AND TGF-βIN THE CENTRAL NERVOUS SYSTEM AND SERUM OF MICE WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 7(1), 54-65. SID. https://sid.ir/paper/326361/en

Vancouver: Copy

JAFARZADEH ABDOLLAH, AHANGAR PARVIN REYHANE, NEMATI MARYAM, TAGHIPOUR ZAHRA, SHAMSIZADEH ALI, AYOOBI FATEMEH, ZUHAIR MOHAMMAD HASSAN. GINGER EXTRACT MODULATES THE EXPRESSION OF IL-12 AND TGF-βIN THE CENTRAL NERVOUS SYSTEM AND SERUM OF MICE WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2017;7(1):54-65. Available from: https://sid.ir/paper/326361/en

IEEE: Copy

ABDOLLAH JAFARZADEH, REYHANE AHANGAR PARVIN, MARYAM NEMATI, ZAHRA TAGHIPOUR, ALI SHAMSIZADEH, FATEMEH AYOOBI, and MOHAMMAD HASSAN ZUHAIR, “GINGER EXTRACT MODULATES THE EXPRESSION OF IL-12 AND TGF-βIN THE CENTRAL NERVOUS SYSTEM AND SERUM OF MICE WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 7, no. 1, pp. 54–65, 2017, [Online]. Available: https://sid.ir/paper/326361/en

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