Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats

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MOKHTARI HASHTJINI MINA; Pirzad Jahromi Gila; MEFTAHI GHOLAM HOSSEIN; ESMAEILI DAVOUD; JAVIDNAZAR DANIAL

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Journal: Avicenna Journal of Phytomedicine Year:2018 | Volume:8 | Issue:4 Page(s): 358-369

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Title

Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats

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Keywords

Deep brain stimulation

Saffron

Post-traumatic stress disorder

Contextual fear conditioning

Corticosterone

C-Fos protein

Abstract

Post-traumatic stress disorder (PTSD) as one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event. Crocus sativus L., commonly known as Saffron have been traditionally used for treatment of stress and anxiety. In this study, we evaluated the effects of peripheral administration of Saffron, along with Deep brain stimulation (DBS) in a Post-traumatic stress disorder (PTSD) model caused by Contextual fear conditioning (electrical foot shock chamber) in male Wistar rats. Materials and Methods: rats (220-250 g) were divided into 7 groups (n=8) and underwent stereotactic surgery for implantation of the electrodes in the right-baso lateral of the amygdala (BLA). After 7 days, some animals received the foot shock, followed by another 7-day treatment (DBS treatment or combination treatment by Saffron 5 mg/kg (i. p)) then freezing behavior as a predicted response in the absence of the foot shock (re-exposure time) and general anxiety were measured using elevated plus maze test. Serum Corticosterone level and amygdala C-Fos protein expression were assessed using ELISA and Western blot analysis, respectively. Results: DBS treatment and the combination therapy of Saffron (5 mg/kg (I. P)) with DBS significantly (p<0. 001) increased serum Corticosterone levels. Also both treatments could significantly (p<0. 001) reduce C-Fos protein expression and freezing behaviors time. However, DBS treatment had no effect on the general anxiety in rats with PTSD. On the other hand, combination therapy significantly (p<0. 001) reduced anxiety behavior in rats with PTSD. Conclusion: These results might show the potential of this combination therapy for treatment of treatment-resistant PTSD patients.

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APA: Copy

MOKHTARI HASHTJINI, MINA, Pirzad Jahromi, Gila, MEFTAHI, GHOLAM HOSSEIN, ESMAEILI, DAVOUD, & JAVIDNAZAR, DANIAL. (2018). Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 8(4), 358-369. SID. https://sid.ir/paper/326400/en

Vancouver: Copy

MOKHTARI HASHTJINI MINA, Pirzad Jahromi Gila, MEFTAHI GHOLAM HOSSEIN, ESMAEILI DAVOUD, JAVIDNAZAR DANIAL. Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2018;8(4):358-369. Available from: https://sid.ir/paper/326400/en

IEEE: Copy

MINA MOKHTARI HASHTJINI, Gila Pirzad Jahromi, GHOLAM HOSSEIN MEFTAHI, DAVOUD ESMAEILI, and DANIAL JAVIDNAZAR, “Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 8, no. 4, pp. 358–369, 2018, [Online]. Available: https://sid.ir/paper/326400/en

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